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Emerging Antineoplastic Gold Nanomaterials for Cervical Cancer Therapeutics: A Systematic Review

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Abstract

Cervical cancer, a malignant neoplasm arising from cervix cells, remains one of the leading global cause of women cancer-related deaths. The present study was aimed to conduct a comprehensive systematic review to show the anticancer activity of biological mediated gold nanoparticles (AuNPs) against cervical cancer cells. To identify the articles, a systematic search was performed through the electronic databases including Web of Science, PubMed, Scopus, Science Direct, ProQuest, Embase, and Cochrane for the articles published up to 31 August 2019. Thirty-three articles met our eligibility criteria and were entered into the present systematic review. Our finding showed that twenty-eight articles stated the biogenic AuNPs-induced cytotoxicity against cervical cancer cells, whereas five reports said no cytotoxicity. In this study, the proposed molecular mechanisms of biogenic AuNPs-induced cytotoxicity were discussed. In total, the studies suggested the induction of apoptosis and overgeneration of intracellular reactive oxygen species (ROS) through the AuNPs-treated cervical cells. The information of this study may help the researchers for translation laboratory setting studies to clinical researches. Future investigations are required to represent the efficacy of biogenic AuNPs through in vivo models alone or combination with other anticancer drugs.

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Acknowledgments

This work was financially supported by Shahid Beheshti University of Medical Sciences, Tehran, Iran (Grant Number 20417).

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Authors and Affiliations

  1. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hamed Barabadi, Hossein Vahidi & Zahra Kosar

  2. Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Ali Mahjoub

  3. Golestan University of Medical Sciences, Food and Drug Administration, Gorgan, Iran

    Kaveh Damavandi Kamali

  4. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia

    Karuppiah Ponmurugan

  5. Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Omid Hosseini

  6. School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

    Masoumeh Rashedi

  7. Department of Medical Microbiology and Immunology, Institute of Biomedical Sciences, College of Health Sciences, Mekelle University, 1871, Mekelle, Ethiopia

    Muthupandian Saravanan

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  1. Hamed Barabadi
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Correspondence to Hamed Barabadi, Masoumeh Rashedi or Muthupandian Saravanan.

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Barabadi, H., Vahidi, H., Mahjoub, M.A. et al. Emerging Antineoplastic Gold Nanomaterials for Cervical Cancer Therapeutics: A Systematic Review. J Clust Sci 31, 1173–1184 (2020). https://doi.org/10.1007/s10876-019-01733-2

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