A Highly Porous Co-MOF for Cyanosilylation Reaction and Inhibition on P. gingivalis Growth and rgp and kgp Expression for Periodontal Treatment

Abstract

A novel porous three-dimensional Co(II) organic framework of metal, [{Co2(TCPP)(H2O)}·DMF]n (1), (where H4TCPP = 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine) was synthesized under the solvent thermal condition, consisting of a H4TCPP ligand which is rigid and tetratopic. Intriguingly, the centers of Co(II) coordinated water molecules can be dislodged via activating 1 under 120 °C, resulting in a pores skeleton arranged by Lewis acidic Co(II) ions which are unsaturated. Activated 1 has great activity of catalysis for without solvent cyanosilylation of acetaldehydes under mild conditions. To develop the candidates for the periodontal diseases therapy, the inhibitory effect of the compound on the growth curves of Porphyromonas gingivalis was evaluated. Next, the RT-PCR detection of rgp and kgp was conducted to explore the effect of compound on the key gene expression.

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Acknowledgements

This work was supported by Grants from Scientific Research Topics of Heilongjiang Health and Family Planning Commission (2017-412).

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Correspondence to Li-Bo Zhou.

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Dai, XP., Hou, YZ., Guan, J. et al. A Highly Porous Co-MOF for Cyanosilylation Reaction and Inhibition on P. gingivalis Growth and rgp and kgp Expression for Periodontal Treatment. J Clust Sci 31, 1077–1085 (2020). https://doi.org/10.1007/s10876-019-01714-5

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Keywords

  • MOF
  • Hetero-donor organic ligand
  • Porous framework
  • Cyanosilylation reaction
  • Periodontal diseases