Synthesis of Chiral Penicillamine-Coated Gold Nanoparticles and Effect on PC12 Cells for the Treatment of Alzheimer’s Disease

Abstract

Recently, nano-scaled chirality has attained significant attraction from various research areas depending on its fundamental significance in the matter of living and nature. In this work, we designed and fabricated d-/l-Pe-Au nanoparticles (Chiral Penicillamine-modified Gold NPs), system for the treatment of Alzheimer’s disease. RTCA (real-time cell analysis) assay was performed using rat PC12 (Pheochromocytoma) cells to investigate the capable cytotoxicity of d-/l-Pe-Au nanoparticles. At any point of given time, with increase in the concentration of d-Pe-Au nanoparticles, we observed a significant decrease in the cell index, which suggests that the cytotoxic effect on the PC12 cells depends on the concentration. We believe that the results obtained may be significant for other chiral nanoparticles in the treatment of the disease called Alzheimer’s and also has an extensive utilization in the studies and applications based on NPs.

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Correspondence to Qingdong Wu.

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Wu, Q., Cao, C., Yan, F. et al. Synthesis of Chiral Penicillamine-Coated Gold Nanoparticles and Effect on PC12 Cells for the Treatment of Alzheimer’s Disease. J Clust Sci 31, 1071–1075 (2020). https://doi.org/10.1007/s10876-019-01712-7

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Keywords

  • d-/l-Pe-AuNPs
  • PC12 cells
  • Alzheimer’s disease
  • RTCA