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Antimicrobial, Cytotoxicity and Photocatalytic Degradation of Norfloxacin Using Kleinia grandiflora Mediated Silver Nanoparticles

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Abstract

Synthesis of nanomaterials through green and eco-friendly approaches which are free from toxic chemicals is an emerging interest in the field of nanoscience and nanotechnology. Plant-mediated synthesis of silver nanoparticles (AgNPs) gained importance because of its non-toxic, eco-friendly and potential for biomedical applications. The present study explored the synthesis of AgNPs using Kleinia grandiflora leaf extract (KGLE) as a reducing and stabilizing agent. The synthesized AgNPs were characterized via UV–Vis spectroscopy (UV–Vis), Fourier transform-infrared spectroscopy, X-ray diffraction, scanning electron microscopy, transmission electron microscopy and energy dispersive X-ray spectroscopy. The biosynthesized AgNPs were found to be spherical in shape and particle size in the range of 20–50 nm. Besides, the synthesized AgNPs showed significant antimicrobial efficacy against Pseudomonas aeruginosa and Aspergillus niger as well as considerable cytotoxicity towards Dalton’s lymphoma ascites cells with 100% inhibition at the concentration of 200 µg/mL of Ag-NPs. Furthermore, the photocatalytic degradation of norfloxacin under visible light irradiation explored the better reducing ability after 80 min of exposure time It is envisioned that KGLE mediated synthesized AgNPs may have a better antimicrobial, cytotoxic and photocatalytic agent in future.

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Acknowledgements

This research did not receive any specific grant from funding agencies in the public, commercial and other sectors.

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Authors and Affiliations

  1. Department of Chemistry, SNS College of Technology, Coimbatore, 641035, India

    Krishnaswamy Kanagamani

  2. Department of Chemistry, Faculty of Engineering, Karpagam Academy of Higher Education, Coimbatore, 641021, India

    Pitchaipillai Muthukrishnan, Karikalan Shankar & Ayyasami Kathiresan

  3. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hamed Barabadi

  4. Department of Medical Microbiology and Immunology, Institute of Biomedical Sciences, College of Health Sciences, Mekelle University, 1871, Mekelle, Ethiopia

    Muthupandian Saravanan

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  1. Krishnaswamy Kanagamani
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  2. Pitchaipillai Muthukrishnan
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  3. Karikalan Shankar
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  4. Ayyasami Kathiresan
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  6. Muthupandian Saravanan
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Correspondence to Pitchaipillai Muthukrishnan or Muthupandian Saravanan.

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Kanagamani, K., Muthukrishnan, P., Shankar, K. et al. Antimicrobial, Cytotoxicity and Photocatalytic Degradation of Norfloxacin Using Kleinia grandiflora Mediated Silver Nanoparticles. J Clust Sci 30, 1415–1424 (2019). https://doi.org/10.1007/s10876-019-01583-y

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