Abstract
A new porous metal–organic framework (MOF) [Zn2(ad)2(fmdb)(H2O)](DMF)3 (1, DMF = N,N-dimethylformamide) based on zinc(II) ions, biomolecular adenine (Had) and 4,4′-(fluoromethylene)dibenzoic acid (H2fmdb) has been successfully obtained via a one-pot solvothermal reaction. The structural analysis via the single crystal X-ray diffraction reveals that compound 1 locates in the monoclinic space group C2/c and demonstrates a three-dimensional channel-type neutral framework. The as-prepared complex 1 exhibits low toxicity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay, revealing its potential application in human health care. In light of its nano-sized channel space and good stability in biological buffers solution, the activated compound 1 (1a) has been applied as a carrier for loading the anticancer drug 5-Fu (5-Fluorouracil) though a simple adsorption process. The successful loading of 5-Fu was confirmed by the gas sorption measurement and the loading capacity was determined by UV–Vis spectroscopy, which reveals a drug loading capacity of 44.6 wt%. The drug delivery in the simulated cancerous tissues (pH = 5.0) exhibited a more complete release in comparison with that in the normal tissues (pH = 7.4), demonstrating the compound 1a could be potentially used as a pH-controlled drug delivery carrier. In connection to these, in vitro anticancer activity of 5-Fu loaded 1a was also evaluated using MTT assays against two human cervical cancer cells HeLa and SiHa.
Similar content being viewed by others
Change history
29 January 2024
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s10876-024-02584-2
References
G. Chang, B. Li, H. Wang, T. Hu, Z. Bao, and B. Chen (2016). Chem. Commun. 52, 3494.
W. Y. Gao, T. Pham, K. A. Forrest, B. Space, L. Wojtas, Y. S. Chen, and S. Ma (2015). Chem. Commun. 51, 9636.
D. M. Chen, N. N. Zhang, J. Y. Tian, C. S. Liu, and M. Du (2017). Inorg. Chem. 56, 7328.
J. N. Hao and B. Yan (2016). Nanoscale 8, 12047.
B. Lei, M. Wang, Z. Jiang, W. Qi, R. Su, and Z. He (2018). ACS Appl. Mater. Interfaces 10, 16698.
L. Wang, M. Zheng, and Z. Xie (2018). J. Mater. Chem. B 6, 707.
K. Jiang, L. Zhang, Q. Hu, Y. Yang, W. Lin, Y. Cui, Y. Yang, and G. Qian (2018). Mater. Lett. 225, 142.
D. Chen, X. Zhang, W. Shi, and P. Cheng (2014). Cryst. Growth Des. 14, 6261.
G. N. Lucena, R. C. Alves, M. P. Abuçafy, L. A. Chiavacci, I. C. da Silva, F. R. Pavan, and R. C. G. Frem (2018). J. Solid State Chem. 260, 67.
X. Du, R. Fan, L. Qiang, K. Xing, H. Ye, X. Ran, Y. Song, P. Wang, and Y. Yang (2017). ACS Appl. Mater. Interfaces 9, 28939.
W. Lin, Q. Hu, J. Yu, K. Jiang, Y. Yang, S. Xiang, Y. Cui, Y. Yang, Z. Wang, and G. Qian (2016). Chempluschem 81, 804.
Q. Hu, J. Yu, M. Liu, A. Liu, Z. Dou, and Y. Yang (2014). J. Med. Chem. 57, 5679.
F. Shu, D. Lv, X. L. Song, B. Huang, C. Wang, Y. Yu, and S. C. Zhao (2018). RSC Adv. 8, 6581.
F. Li, B. Li, C. Wang, Y. Zeng, J. Liu, C. Y. Gu, P. Lu, and L. Mei (2016). RSC Adv. 6, 47959.
E. A. Giles-Mazón, I. Germán-Ramos, F. Romero-Romero, E. Reinheimer, R. A. Toscano, N. Lopez, C. E. Barrera-Díaz, V. Varela-Guerrero, and M. F. Ballesteros-Rivas (2018). Inorganica Chim. Acta 469, 306.
C. Wang, L. Tian, W. Zhu, S. Wang, P. Wang, Y. Liang, W. Zhang, H. Zhao, and G. Li (2017). ACS Appl. Mater. Interfaces 9, 20076.
J. An, O. K. Farha, J. T. Hupp, E. Pohl, J. I. Yeh, and N. L. Rosi (2012). Nat. Commun. 3, 604.
T. Li, D. L. Chen, J. E. Sullivan, M. T. Kozlowski, J. K. Johnson, and N. L. Rosi (2013). Chem. Sci. 4, 1746.
J. Li, X. H. Ji, and J. T. Li (2017). J. Mol. Struct. 1147, 22.
J. Li and J. T. Li (2018). Inorg. Chem. Comm. 89, 51.
J. T. Li, J. Li, L. M. Song, and X. H. Ji (2017). Inorg. Chem. Commun. 83, 88.
Author information
Authors and Affiliations
Corresponding author
Additional information
This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s10876-024-02584-2
Electronic supplementary material
Below is the link to the electronic supplementary material.
About this article
Cite this article
Wang, ZC., Zhang, Y. & Li, ZY. RETRACTED ARTICLE: A Low Cytotoxic Metal–Organic Framework Carrier: pH-Responsive 5-Fluorouracil Delivery and Anti-Cervical Cancer Activity Evaluation. J Clust Sci 29, 1285–1290 (2018). https://doi.org/10.1007/s10876-018-1446-7
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10876-018-1446-7