Journal of Cluster Science

, Volume 28, Issue 4, pp 2337–2348 | Cite as

Solution Combustion Synthesis of Hierarchically Structured V2O5 Nanoflakes: Efficacy Against Plasmodium falciparum, Plasmodium berghei and the Malaria Vector Anopheles stephensi

  • Kadarkarai Murugan
  • Christina Mary Samidoss
  • Jayaraman Theerthagiri
  • Chellasamy Panneerselvam
  • Jagannathan Madhavan
  • Aruliah Rajasekar
  • Angelo Canale
  • Giovanni Benelli
Original Paper


The effective prevention and treatment of malaria still represent a major public health challenge. Here, the solution combustion method was used for the synthesis of hierarchically structured V2O5 nanoflakes. The toxicity of V2O5 nanoflakes was evaluated on the malaria vector Anopheles stephensi and on the malaria parasites Plasmodium falciparum and P. berghei, relying to in vitro and in vivo assays. V2O5 nanoflakes were examined by various techniques, including powder X-ray diffraction, field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (XRD), and high resolution transmission electron microscopy (HR-TEM). LC50 of V2O5 nanoflakes against A. stephensi larvae and pupae were 1.936 ppm (larva I), 3.606 ppm (II), 4.750 ppm (III), 6.636 ppm (IV), and 8.876 ppm (pupae). Furthermore, the antiplasmodial activity of V2O5 nanoflakes was evaluated against chloroquine-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of P. falciparum. IC50 of V2O5 nanoflakes were 84.54 μg/ml (CQ-s) and 88.17 μg/ml (CQ-r). In vivo antiplasmodial experiments conducted on P. berghei infecting albino mice showed moderate activity of V2O5 nanoflakes, if compared to chloroquine. Overall, our results highlighted the promising potential of the solution combustion method for the synthesis of hierarchically structured V2O5 nanoflakes, which showed really high efficacy as mosquito larvicides and pupicides.


Chemosuppression Larvicide Malaria Nanosynthesis 


Compliance with Ethical Standards

Conflict of interest

The authors declare no competing interests.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Kadarkarai Murugan
    • 1
    • 2
  • Christina Mary Samidoss
    • 1
  • Jayaraman Theerthagiri
    • 3
  • Chellasamy Panneerselvam
    • 4
  • Jagannathan Madhavan
    • 3
  • Aruliah Rajasekar
    • 5
  • Angelo Canale
    • 6
  • Giovanni Benelli
    • 6
  1. 1.Department of ZoologyBharathiar UniversityCoimbatoreIndia
  2. 2.Thiruvalluvar UniversityVelloreIndia
  3. 3.Solar Energy Lab, Department of ChemistryThiruvalluvar UniversityVelloreIndia
  4. 4.Faculty of Science, Department of BiologyUniversity of TabukTabukSaudi Arabia
  5. 5.Department of BiotechnologyThiruvalluvar UniversityVelloreIndia
  6. 6.Department of Agriculture, Food and EnvironmentUniversity of PisaPisaItaly

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