Green Nanosynthesis and Functionalization of Gold Nanoparticles as PTP 1B Inhibitors
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Nanomedicine has emerged to become a frontier area of research. The interdisciplinary nature of nanoscale research inevitably leads to nanostructure fabrication and functionalization. Herein, we addressed on the potential of high therapeutic indexed Syzygium cumini seed to biofunctionalize gold nanoparticles. The aqueous seed extract of S. cumini acted as a reducing and capping agent in the formation of gold nanoparticles. Biofabricated gold nanoparticles was characterized using UV–vis spectrophotometry, TEM, SEM, EDAX, FTIR and XRD analysis. PTP 1B inhibitory activity of bioinspired gold nanoparticles was assessed using PTP 1B inhibition assay. Newly synthesized gold nanoparticles was found to possess high PTP 1B inhibitory potential. Furthermore, the newly synthesized nanoparticles not shown any genotoxicity during chromosomal studies indicates its high biocompatibility nature.
KeywordsNanomedicine Syzygium cumini Gold nanoparticles PTP 1B inhibition assay Genotoxicity Chromosomal studies
The financial support from the Department of Biotechnology (DBT), Government of India, New Delhi, (BT/508/NE/TBP/2013) to carry out this study, is gratefully acknowledged. We thank the SAIF, IIT Bombay for technical support in the characterization of nanoparticles.
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