Isolation of a Decavanadate Cluster [H₂V₁₀O₂₈][4-picH]₄·2H₂O (4-pic = 4-picoline): Crystal Structure, Electrochemical Characterization, Genotoxic and Antimicrobial Studies

Abstract

The studies on polyoxovanadate clusters have received considerable attentions due to their interesting structures and extensive applications in material science and medicinal chemistry. A novel decavanadate cluster with composition [H₂V₁₀O₂₈][4-pic]₄·2H₂O has been synthesized in aqueous solution and characterized by spectral (FTIR, ⁵¹V NMR, EPR and Mass) and electrochemical studies. Single crystal X-ray crystallographic investigations indicate that decavanadate anion [H₂V₁₀O₂₈]⁴⁻ and the protonated counter cations (4-picH⁺) stabilize the crystal lattice giving a 2D sheet consolidated via extensive H-bonding interactions. Cyclic voltammetric studies indicate formation of stable quasi-reversible redox couple $\left( {{\text{V}}^{\text{V}} \overset {} \rightleftharpoons {\text{V}}^{\text{IV}} } \right)$ in solution. The genotoxic studies employing single cell gel electrophoresis and plasmid nicking assay ascertained the non toxic nature of the compound. The complex has also been tested for in vitro antimicrobial activities against gram +ve and gram −ve bacteria and fungi. The compound can thus be exploited as antimicrobial agent since it does not cause any toxicity or damage to DNA.