Skip to main content

Advertisement

SpringerLink
Log in

RAS-associated Autoimmune Leukoproliferative Disease (RALD-KRAS) Consistent with the Clinical Diagnosis of Rosai-Dorfman Disease: A 15-year Follow-up

  • Research
  • Published:
Journal of Clinical Immunology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Data Availability

No datasets were generated or analysed during the current study.

References

  1. Calvo KR, Price S, Braylan RC, et al. JMML and RALD (ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities. Blood. 2015;125(18):2753–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ragotte RJ, Dhanrajani A, Pleydell-Pearce J, et al. The importance of considering monogenic causes of autoimmunity: a somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus. Clin Immunol. 2017;175:143–6.

    Article  CAS  PubMed  Google Scholar 

  3. Lanzarotti N, Bruneau J, Trinquand A, et al. RAS-associated lymphoproliferative disease evolves into severe juvenile myelo-monocytic leukemia. Blood. 2014;123(12):1960–3.

    Article  CAS  PubMed  Google Scholar 

  4. Aringer M, Costenbader K, Daikh D, et al. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for systemic Lupus Erythematosus. Arthritis Rheumatol. 2019;71(9):1400–12.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Niemela JE, Lu L, Fleisher TA, et al. Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis. Blood. 2011;117(10):2883–6.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We greatly thank Dr. Wei Lin and Wenmei Wang from Xiangya Hospital of Central South University for helping analyze the tissue samples.

Funding

This study was funded by National Natural Sciences Foundation of China [82271280 to YT and 82301433 to JJW], Hunan Provincial Natural Science Foundation of China [No. 2022JJ40824 to JJW], Scientific Research Project of Hunan Provincial Health Commission [No. B202303070054 to YT], Talents Startup Fund [No. 2209090550 to YT], Youth Science Fund [No. 2021Q04 to JJW] and Project Program of National Clinical Research Center for Geriatric Disorders [No. 2022LNJJ14 to HJZ] of Xiangya Hospital, Central South University, Changsha, China.

Author information

Authors and Affiliations

  1. Aging Research Center, Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, 410008, China

    Yu Tang & Huakun Wang

  2. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China

    Yu Tang, Huakun Wang, Hongjun Zhao & Junjiao Wu

  3. Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, 410008, China

    Hongjun Zhao & Junjiao Wu

  4. Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Central South University, Changsha, 410008, China

    Hongjun Zhao & Junjiao Wu

  5. Department of Respiratory Medicine, Hunan Provincial Children’s Hospital, Changsha, 410007, China

    Shijie Jin

Authors
  1. Yu Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Huakun Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hongjun Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shijie Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Junjiao Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

J.W. and Y.T. conceived this study and designed the experiments. J.W., H.W., H.Z. and S.J. collected clinic and experimental data. J.W. and Y.T. prepared and revised the manuscript draft.

Corresponding author

Correspondence to Junjiao Wu.

Ethics declarations

Competing Interests

The authors have declared that no competing interest exists.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic Supplementary Material

Below is the link to the electronic supplementary material.

Supplementary Material 1

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tang, Y., Wang, H., Zhao, H. et al. RAS-associated Autoimmune Leukoproliferative Disease (RALD-KRAS) Consistent with the Clinical Diagnosis of Rosai-Dorfman Disease: A 15-year Follow-up. J Clin Immunol 44, 123 (2024). https://doi.org/10.1007/s10875-024-01728-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10875-024-01728-3

Search

Navigation