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Pharmacokinetics of Baricitinib in Cerebrospinal Fluid and Plasma in a Patient with SPENCD

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Data Availability

No datasets were generated or analysed during the current study.

References

  1. Frémond ML, Hully M, Fournier B, Barrois R, Lévy R, Aubart M, et al. JAK inhibition in Aicardi-Goutières Syndrome: a Monocentric Multidisciplinary Real-World Approach Study. J Clin Immunol. 2023;43(6):1436–47.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, et al. The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS. Ann Rheum Dis. 2022;81(5):601–13.

    Article  PubMed  Google Scholar 

  3. Briggs TA, Rice GI, Adib N, Ades L, Barete S, Baskar K, et al. Spondyloenchondrodysplasia due to mutations in ACP5: a Comprehensive Survey. J Clin Immunol. 2016;36(3):220–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Vanderver A, Adang L, Gavazzi F, McDonald K, Helman G, Frank DB, et al. Janus Kinase Inhibition in the Aicardi-Goutières Syndrome. N Engl J Med. 2020;383(10):986–9.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Kim H, Brooks KM, Tang CC, Wakim P, Blake M, Brooks SR, et al. Pharmacokinetics, Pharmacodynamics, and proposed dosing of the oral JAK1 and JAK2 inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI patients. Clin Pharmacol Ther. 2018;104(2):364–73.

    Article  CAS  PubMed  Google Scholar 

  6. An J, Briggs TA, Dumax-Vorzet A, Alarcón-Riquelme ME, Belot A, Beresford M, et al. Tartrate-resistant Acid Phosphatase Deficiency in the predisposition to systemic Lupus Erythematosus. Arthritis Rheumatol. 2017;69(1):131–42.

    Article  CAS  PubMed  Google Scholar 

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Funding

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Authors and Affiliations

  1. Division of Paediatric Rheumatology, Department of Paediatrics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada

    Micol Romano, Erkan Demirkaya & Roberta A. Berard

  2. Division Hematology and Oncology, Children’s Hospital at London Health Sciences Centre, Western University, London, ON, Canada

    Ashley Geerlink

  3. Division of Pediatric Clinical Pharmacology, Department of Pediatrics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada

    Facundo Garcia-Bournissen

Authors
  1. Micol Romano
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  2. Erkan Demirkaya
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  3. Roberta A. Berard
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  4. Facundo Garcia-Bournissen
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Contributions

Contribution to the conception or design of the work: MR, FGB. Drafting the work or revising it critically: MR, AG, ED, RAB, FGB.

Corresponding author

Correspondence to Micol Romano.

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The authors declare no competing interests.

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Romano, M., Geerlink, A., Demirkaya, E. et al. Pharmacokinetics of Baricitinib in Cerebrospinal Fluid and Plasma in a Patient with SPENCD. J Clin Immunol 44, 78 (2024). https://doi.org/10.1007/s10875-024-01680-2

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  • DOI: https://doi.org/10.1007/s10875-024-01680-2

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