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Vanishing Lymphocytes in a Case of Vanishing Bone Disease

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References

  1. Dellinger MT, et al. Viewpoints on vessels and vanishing bones in Gorham-Stout disease. Bone. 2014;63:47–52.

    Article  PubMed  Google Scholar 

  2. Alberto Valsecchi, et al. Pleural effusion in Gorham-Stout syndrome: a case report and a literature review. Cancers Rev, Conscientia Beam. 2015;2(2):11–22.

    Article  Google Scholar 

  3. Wu JK, Kitajewski C, Reiley M, Keung CH, Monteagudo J, et al. Aberrant lymphatic endothelial progenitors in lymphatic malformation development. PLoS One. 2015;10(2):e0117352.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Ricci KW, Hammill AM, Mobberley-Schuman P, Nelson SC, Blatt J, Bender JLG, McCuaig CC, Synakiewicz A, Frieden IJ, Adams DM. Efficacy of systemic sirolimus in the treatment of generalized lymphatic anomaly and Gorham-Stout disease. Pediatr Blood Cancer. 2019;66(5):e27614.

    Article  PubMed  PubMed Central  Google Scholar 

  5. El Fenniri L, Toossi Z, Aung H, El Iraki G, Bourkkadi J, Benamor J, Laskri A, Berrada N, Benjouad A, Mayanja-Kizza H, Betts MR, El Aouad R, Canaday DH. Polyfunctional Mycobacterium tuberculosis-specific effector memory CD4+ T cells at sites of pleural TB. Tuberculosis (Edinb). 2011;91(3):224–30.

    Article  Google Scholar 

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Acknowledgements

We would like to acknowledge Dr. Zinet Currimbhoy who started the immunology department at B. J. Wadia Hospital for Children in the early 2000s and continues to support and mentor the department; Dr. Sudha Rao, Dr. Lakshmi Shobhavat, Dr. Parmarth Chandane, and Dr. Rajesh Joshi from Bai Jerbai Wadia Hospital for Children for patient referral and management; Dr. Prashant Tembhare, Advanced Centre for Treatment Research & Education in Cancer, Tata Memorial Centre (ACTREC), for VEGF assay; Dr. Yash Jain, Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Parel, for providing CT PET and bone scan images; Dr. Anita Borges and Dr. Pravin Mahajan S.L Raheja Hospital, Mumbai, for processing the biopsy specimen with D2-40 immunostain and providing biopsy images.

COE consortium:

Akshaya Chougule1, Minnie Bodhanwala1, Umair A. Bargir2, Manisha Madkaikar2

1Bai Jerbai Wadia Hospital for Children, Parel, Mumbai, Maharashtra, India

2National Institute of Immunohaematology, ICMR, 13th floor New Building, KEM Hospital, Mumbai, Maharashtra, India

Funding

The study was partly funded by the Indian Council of Medical Research (ICMR), New Delhi, India, under the Centre of Excellence in the PID project (vide Grant No.61/02/2012/IMM/BMS).

Author information

Authors and Affiliations

  1. Department of Immunology, Bai Jerbai Wadia Hospital for Children, Acharya Dhonde Marg, Parel, Mumbai, Maharashtra, 400012, India

    Vaishnavi V. Iyengar, Vijaya Gowri, Prasad Taur, Akshaya Chougule, Minnie Bodhanwala & Mukesh M. Desai

  2. National Institute of Immunohaematology, ICMR, 13th Floor New Building, KEM Hospital, Mumbai, Maharashtra, 400012, India

    Umair A. Bargir & Manisha Madkaikar

Authors
  1. Vaishnavi V. Iyengar
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  2. Vijaya Gowri
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  3. Prasad Taur
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  4. Mukesh M. Desai
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Consortia

COE consortium

  • Akshaya Chougule
  • , Minnie Bodhanwala
  • , Umair A. Bargir
  •  & Manisha Madkaikar

Contributions

Vaishnavi V. Iyengar conceptualized and designed the study, performed the collection and analysis of data, drafted the initial manuscript, and reviewed and revised the manuscript.

Vijaya Gowri collected the data, carried out the initial analysis, and reviewed and revised the manuscript.

Prasad Taur collected the data and reviewed and revised the manuscript.

Mukesh M Desai conceptualized the study, supervised the study, interpreted the data, and critically revised the article.

COE consortium:

Akshaya Chougule collected the data, carried out the initial analysis, and reviewed and revised the manuscript.

Minnie Bodhanwala supervised data collection and critically revised the article.

Umair Bargir and Manisha Madkaikar performed the immunological workup of the patient, collected the data, and reviewed and revised the manuscript.

Corresponding author

Correspondence to Mukesh M. Desai.

Ethics declarations

Ethics approval and consent to participate

Ethics approval was taken from our institute. Written informed consent was taken from the guardian of the child included in the study.

Consent for publication

The authors affirm that the guardian provided informed consent for publication of the images.

Conflict of interest

The authors declare no competing interests.

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Cite this article

Iyengar, V.V., Gowri, V., Taur, P. et al. Vanishing Lymphocytes in a Case of Vanishing Bone Disease. J Clin Immunol 42, 706–708 (2022). https://doi.org/10.1007/s10875-022-01212-w

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  • DOI: https://doi.org/10.1007/s10875-022-01212-w

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