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A Novel Case of Complement Factor B Deficiency

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References

  1. Audemard-Verger A, Descloux E, Ponard D, Deroux A, Fantin B, Fieschi C, et al. Infections revealing complement deficiency in adults a French nationwide study enrolling 41 patients. Medicine. 2016;95(19):e3548.

    Article  CAS  Google Scholar 

  2. López-Lera A, Corvillo F, Nozal P, Regueiro JR, Sánchez-Corral P, López-Trascasa M. Complement as a diagnostic tool in immunopathology. Semin Cell Dev Biol. 2019;85:86–97.

    Article  Google Scholar 

  3. Slade C, Bosco J, Unglik G, Bleasel K, Nagel M, Winship I. Deficiency in complement factor B. N Engl J Med. 2013;369(17):1667–9.

    Article  CAS  Google Scholar 

  4. Tong HH, Li XY, Stahl GL, Thurman JM. Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2. Infect Immun. 2010;78(3):976–83.

    Article  CAS  Google Scholar 

  5. Ponnuraj K, Xu Y, Macon K, Moore D, Volanakis JE, Narayana SV. Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Mol Cell. 2004;14(1):17–28.

    Article  CAS  Google Scholar 

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Acknowledgments

We thank Dr. Manuel Galvan of the Complement Laboratory at National Jewish Health for helpful discussions.

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Correspondence to Amélie Gauthier.

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Gauthier, A., Wagner, E., Thibeault, R. et al. A Novel Case of Complement Factor B Deficiency. J Clin Immunol 41, 277–279 (2021). https://doi.org/10.1007/s10875-020-00906-3

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  • DOI: https://doi.org/10.1007/s10875-020-00906-3

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