Skip to main content

Advertisement

Log in

Different Clonal T-Large Granular Lymphocyte Proliferations in SCID

  • Letter to Editor
  • Published:
Journal of Clinical Immunology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Abbreviations

CMV:

Cytomegalovirus

EBV:

Epstein-Barr virus

GvHD:

Graft versus host disease

IVIG:

Intravenous immunoglobulin

JAK3:

Janus Kinase 3

LGL:

Large granular lymphocytes

SCID:

Severe combined immunodeficiency

STAT:

Signal transducer and activator of transcription 3

STR:

short tandem repeat

T-LGL:

T-large granular lymphocyte

TCR:

T cell receptor

UCBT:

Umbilical cord blood transplantation

References

  1. Lamy T, Moignet A, Loughran TP Jr. LGL leukemia: from pathogenesis to treatment. Blood. 2017;129:1082–94.

    Article  CAS  PubMed  Google Scholar 

  2. Savola P, Brück O, Olson T, Kelkka T, Kauppi MJ, Kovanen PE, et al. Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. Haematologica. 2018;103:304–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Demonchy E, Pulcini C. Three cases of primary EBV infection in young adults manifested by periorbital and eyelid oedema. Infection. 2013;41:1029–30.

    Article  PubMed  Google Scholar 

  4. Lev A, Simon AJ, Ben-Ari J, Takagi D, Stauber T, Trakhtenbrot L, et al. Co-existence of clonal expanded autologous and transplacental-acquired maternal T cells in recombination activating gene-deficient severe combined immunodeficiency. Clin Exp Immunol. 2014;176:380–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Nann-Rütti S, Tzankov A, Cantoni N, Halter J, Heim D, Tsakiris D, et al. Large granular lymphocyte expansion after allogeneic hematopoietic stem cell transplant is associated with a cytomegalovirus reactivation and shows an indolent outcome. Biol Blood Marrow Transplant. 2012;18:1765–70.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Süreyya Savaşan.

Ethics declarations

Conflict of Interest Disclosure

The authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Savaşan, S., Wakeling, E., Knight, T. et al. Different Clonal T-Large Granular Lymphocyte Proliferations in SCID. J Clin Immunol 39, 245–248 (2019). https://doi.org/10.1007/s10875-019-00614-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10875-019-00614-7

Navigation