|
Treatment interval
|
Patient number (n)
|
Geometric mean (95 % CI)
|
Median (95 % CI)
|
Min; max
|
|---|
|
IGIV 10 %
|
|
3 weeks
| |
19
|
11.58 (10.36–12.94)
|
12.00 (11.00–14.10)
|
5.45;14.50
|
|
4 weeks
| |
50
|
10.19 (9.55–10.88)
|
10.20 (9.61–11.30)
|
6.09;18.50
|
|
IGSC 20 %
|
|
1 week
|
145 % of IV dose
|
27
|
14.77 (13.86–15.74)
|
15.30 (12.80–16.10)
|
12.00;20.30
|
|
1 week
|
Adjusted dose (145 % of IV dose)
|
66
|
14.20 (13.48–14.96)
|
14.65 (13.80–15.60)
|
8.65;22.20
|
|
1 week
|
Individualized dosea
|
57
|
14.74 (14.03–15.48)
|
15.10 (14.00–16.40)
|
8.81;23.40
|
-
95 %CI 95 % confidence interval
-
aDetermined for each patient by comparing the individual serum IgG trough level attained in period 3 to the expected increase in serum IgG trough level calculated from the PK data from periods 1 and 2