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New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression

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Abstract

Regulatory B (Breg) cells are important regulators of immune responses and in recent years our understanding of their phenotypical and functional characteristics has improved considerably. Initially all suppressive capabilities of Breg cells were attributed to the actions of the anti-inflammatory cytokine interleukin (IL)-10 secreted by Breg cells. Recent studies however, highlight additional and novel mechanisms that influence both the expansion of Breg cells and their capacity to suppress immunity. Here we provide an overview of the complexity of Breg cell populations and address the newly discovered IL-10 independent mechanisms of Breg cell expansion and immune-suppression.

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Acknowledgments

This work was supported by Science Foundation Ireland (PGF), National Children’s Research Centre (PGF) and Irish Research Council (AF).

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Authors and Affiliations

  1. School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

    Achilleas Floudas & Padraic G. Fallon

  2. National Children’s Research Centre, Our Lady’s Children’s Hospital, Dublin, Ireland

    Achilleas Floudas & Padraic G. Fallon

  3. Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden

    Sylvie Amu

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  1. Achilleas Floudas
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Floudas, A., Amu, S. & Fallon, P.G. New Insights into IL-10 Dependent and IL-10 Independent Mechanisms of Regulatory B Cell Immune Suppression. J Clin Immunol 36 (Suppl 1), 25–33 (2016). https://doi.org/10.1007/s10875-016-0263-8

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