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Familial Hepatopulmonary Syndrome in Common Variable Immunodeficiency

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Abstract

Common Variable Immunodeficiency (CVID) comprises a heterogeneous group of primary antibody deficiencies which lead to a range of complications, including infectious, neoplastic and inflammatory disorders. This report describes monozygotic twin brothers with CVID who developed cryptogenic liver disease and subsequently hepatopulmonary syndrome (HPS). This is the second report of the association of HPS and CVID. Its occurrence in two identical twins implicates a genetic basis.

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Acknowledgments

This work was supported by the National Institute of Health Research of the UK, via the Cambridge Biomedical Research Centre.

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Clinical Immunology, Addenbrooke’s Hospital, Hills Road, Box 109, Cambridge, CB2 0QQ, UK

    S. N. Holmes, A. Condliffe & D. S. Kumararatne

  2. Department of Hepatology, Addenbrooke’s Hospital, Hills Road, Cambridge, CB2 0QQ, UK

    W. Griffiths

  3. Centre for Lung Infection, Papworth Hospital, Papworth Everard, Cambridge, CB23 3RE, UK

    H. Baxendale

Authors
  1. S. N. Holmes
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  2. A. Condliffe
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  3. W. Griffiths
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  4. H. Baxendale
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  5. D. S. Kumararatne
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Correspondence to S. N. Holmes.

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Holmes, S.N., Condliffe, A., Griffiths, W. et al. Familial Hepatopulmonary Syndrome in Common Variable Immunodeficiency. J Clin Immunol 35, 302–304 (2015). https://doi.org/10.1007/s10875-015-0142-8

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  • DOI: https://doi.org/10.1007/s10875-015-0142-8

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