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Chronic Recurrent Multifocal Osteomyelitis

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Abstract

Chronic recurrent multifocal osteomyelitis is a rare auto-inflammatory condition that primarily affects children and adolescents. It presents with recurrent episodes of pain related to the presence of foci of sterile bone inflammation. The long bones of the lower extremities are more frequently affected and the spine can also be involved. Imaging studies, including whole-body magnetic resonance, are important for diagnosis and detection of asymptomatic lesions. Bone biopsies may be necessary to exclude other diseases, including malignancy and infections. Non-steroidal anti-inflammatory drugs cause relief of symptoms in the majority of cases. Bisphosphonates and TNF-α blockers are alternatives for patients who do not respond or who have spinal involvement.

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Authors and Affiliations

  1. The Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Research Center 1214, Philadelphia, PA, 19104, USA

    Patrícia Costa-Reis

  2. Divisions of Allergy and Immunology and Rheumatology, Children’s Hospital of Philadelphia, 3615 Civic Center Blvd. ARB 1214, Philadelphia, PA, 19104, USA

    Kathleen E. Sullivan

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  1. Patrícia Costa-Reis
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Correspondence to Patrícia Costa-Reis.

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Costa-Reis, P., Sullivan, K.E. Chronic Recurrent Multifocal Osteomyelitis. J Clin Immunol 33, 1043–1056 (2013). https://doi.org/10.1007/s10875-013-9902-5

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