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Increased Plasma Interleukin-32 Expression in Patients with Neuromyelitis Optica

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Abstract

Purpose

Neuromyelitis optica (NMO) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). The pathogenesis of NMO remains unclear. IL-32 is emerging as a critical molecule in the pathophysiology of immune-mediated chronic inflammatory diseases. Whether IL-32 levels are elevated in NMO patients is unclear. We aimed to determine whether IL-32 levels are elevated in NMO patients and explore its relationship with IL-6, IL-17, and Expanded Disability Status Scale (EDSS) scores.

Methods

Plasma IL-32α, IL-6 and IL-17A were measured by enzyme-linked immunosorbent assay in NMO (n = 26), MS (n = 23) and 22 healthy controls.

Results

We found IL-32α levels were higher in NMO patients compared with MS (p = 0.020) and healthy controls (p = 0.00001). IL-32α levels were increased in MS patients compared with controls (p = 0.009). IL-32α positively correlated with IL-6 and IL-17A levels and EDSS scores in NMO patients.

Conclusions

In summary, plasma IL-32α levels are associated with inflammatory responses in NMO patients.

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Fig. 1

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Conflict of interest

There authors confirm no conflicts of interest.

Funding

This study was supported by the Natural Science Foundation of China (grant no.81200920).

Author information

Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China

    Honghao Wang, Kai Wang & Fangcheng Xu

  2. Multiple Sclerosis Center, Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China

    Honghao Wang, Wei Qiu & Xueqiang Hu

  3. Department of Geriatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China

    Conghui Wang

  4. MS Clinical Research Center, Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou, Guangdong, China

    Xueqiang Hu

Authors
  1. Honghao Wang
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  2. Kai Wang
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  3. Conghui Wang
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  4. Fangcheng Xu
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  5. Wei Qiu
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Corresponding author

Correspondence to Xueqiang Hu.

Additional information

Honghao Wang, Kai Wang and Conghui Wang contributed equally to the manuscript.

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Wang, H., Wang, K., Wang, C. et al. Increased Plasma Interleukin-32 Expression in Patients with Neuromyelitis Optica. J Clin Immunol 33, 666–670 (2013). https://doi.org/10.1007/s10875-012-9837-2

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  • DOI: https://doi.org/10.1007/s10875-012-9837-2

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