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Elevated Serum Resistin in Juvenile IdiopathicArthritis: Relation to Categories and Disease Activity

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Abstract

Background

Juvenile Idiopathic Arthritis (JIA) is one of the more common chronic diseases of childhood that often persists into adulthood and can result in significant long-term morbidity, including physical disability. The aim of the present study was to assess the serum level of resistin in JIA patients and compare its levels according to the categories, clinical manifestations and disease activity.

Methods

Sixty-eight JIA patients and 33 age and sex matched control children were included in the present study. All patients included in this study were subjected to full history taking, clinical examination. Juvenile arthritis disease activity score in 27 joints (JADAS-27) was calculated and Childhood Health Assessment Questionnaire (CHAQ) was used to measure the functional status. Serum resistin levels were measured by enzyme-linked immunosorbent assay (ELISA).

Results

The mean serum resistin was significantly higher in the JIA patients (4.01 ± 2.46 ng/ml) compared to the control (2.08 ± 1.23 ng/ml) (p < 0.001) especially those with systemic-onset. Its level was significantly higher in those receiving steroids and those with a positive antinuclear antibody. Resistin significantly correlated with the JADAS27 (r 0.26, p 0.035) and CHAQ (r 0.4, p 0.001). The JIA patients were 50 females and 18 males; however, the level of resistin was insignificantly different according to the gender although there was a tendency to be higher in females.

Conclusion

Our results reinforce the proposition of an important role for resistin in JIA and may be considered an interesting biomarker for disease activity especially those with systemic onset.

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Authors and Affiliations

  1. Rheumatology Departments, Faculty of Medicine, Cairo University, Cairo, Egypt

    Tamer A. Gheita, Iman I. El-Gazzar & Reem I. El Shazly

  2. Pediatric Department, National Research Centre, Cairo, Egypt

    Abeer M. Nour El-Din

  3. Clinical Pathology Department, National Research Centre, Cairo, Egypt

    Enas Abdel-Rasheed

  4. Medical Microbiology & Immunology Department, Faculty of Medicine, El-Fayoum University, El-Fayoum, Egypt

    Rasha H. Bassyouni

Authors
  1. Tamer A. Gheita
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  2. Iman I. El-Gazzar
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  3. Reem I. El Shazly
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  4. Abeer M. Nour El-Din
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  5. Enas Abdel-Rasheed
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  6. Rasha H. Bassyouni
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Correspondence to Tamer A. Gheita.

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Gheita, T.A., El-Gazzar, I.I., El Shazly, R.I. et al. Elevated Serum Resistin in Juvenile IdiopathicArthritis: Relation to Categories and Disease Activity. J Clin Immunol 33, 297–301 (2013). https://doi.org/10.1007/s10875-012-9760-6

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  • DOI: https://doi.org/10.1007/s10875-012-9760-6

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