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Successful Approach to Treatment of Helicobacter bilis Infection in X-Linked Agammaglobulinemia

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Abstract

Helicobacter bilis, an unusual cause of chronic infections in patients with X-linked agammaglobulinemia (XLA), is notoriously difficult to diagnose and eradicate. Based on the limited number of cases reported worldwide, we highlight the typical features of H. bilis infection in XLA and provide a rational and successful approach to diagnosis and treatment of this challenging infection.

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Authors and Affiliations

  1. Department of Pediatrics, BC Children’s Hospital and Child & Family Research Institute, University of British Columbia, Vancouver, BC, Canada

    Stuart E. Turvey, Sara H. Leo, Julie Prendiville & Anne Junker

  2. University Children’s Hospital, Ludwig Maximilians University, Munich, Germany

    Annette Boos

  3. Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada

    Gregory D. Deans

  4. Department of Pathology and Laboratory Medicine, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada

    Richard I. Crawford

  5. Division of Anatomical Pathology, Children’s & Women’s Health Centre, Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

    Christof Senger

  6. Department of Pediatrics, LeBonheur Children’s Hospital, University of Tennessee College of Medicine, Memphis, TN, USA

    Mary Ellen Conley

  7. Division of Microbiology Virology & Infection Control, BC Children’s and Women’s Hospitals, Vancouver, BC, Canada

    Peter Tilley

  8. BC Centre for Disease Control Public Health Microbiology & Reference Laboratory, Vancouver, BC, Canada

    Loretta Janz & Robert Azana

  9. BC Centre for Disease Control Public Health Microbiology & Reference Laboratory, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

    Linda Hoang

  10. Department of Family Practice, Queen Charlotte Islands General Hospital, Queen Charlotte City, BC, Canada

    Tracy L. Morton

  11. Division of Infectious and Immunological Diseases, BC Children’s Hospital and Child & Family Research Institute, 950 West 28 Avenue, Vancouver, BC, V5Z 4H4, Canada

    Stuart E. Turvey

Authors
  1. Stuart E. Turvey
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  2. Sara H. Leo
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  3. Annette Boos
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  4. Gregory D. Deans
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  5. Julie Prendiville
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  6. Richard I. Crawford
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  7. Christof Senger
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  8. Mary Ellen Conley
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  9. Peter Tilley
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  10. Anne Junker
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  11. Loretta Janz
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  12. Robert Azana
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  13. Linda Hoang
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  14. Tracy L. Morton
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Corresponding author

Correspondence to Stuart E. Turvey.

Additional information

Sources of Support: SET was supported by a Clinical Research Scholar Award from the Michael Smith Foundation for Health Research and by the Chaim Roifman Scholar Award from the Canadian Immunodeficiency Society.

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Turvey, S.E., Leo, S.H., Boos, A. et al. Successful Approach to Treatment of Helicobacter bilis Infection in X-Linked Agammaglobulinemia. J Clin Immunol 32, 1404–1408 (2012). https://doi.org/10.1007/s10875-012-9750-8

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  • DOI: https://doi.org/10.1007/s10875-012-9750-8

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