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Study of the Expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer

Journal of Clinical Immunology volume 32, pages 848–854 (2012)Cite this article

Abstract

Purpose

Dysregulation of toll-like receptors (TLR) signaling can result in chronic inflammatory and over-exuberant repair responses. The aim of this study was to investigate the expression and clinical relevance of TLR in colorectal polyps.

Methods

The expression levels of six TLR were analyzed in 70 patients with different histological types of colorectal polyps, 38 of which developed colorectal carcinoma (CC). These analyses were performed by real-time polymerase chain reaction, western blot, and immunohistochemistry.

Results

TLR9 expression was higher in hyperplastic or adenomatous polyps compared to other polyp types. Hyperplastic polyps also showed increased TLR7 levels compared to the other polyp types. TLR7 expression was lower in both hyperplastic and tubulovillous adenoma polyps from patients who developed CC. TLR9 expression was decreased in hyperplastic and villous polyps from patients who developed CC.

Conclusions

Our findings suggest a possible protective role of TLR expression against malignant transformation in the colorectal mucosa. TLR may represent a pathological marker of CC risk in colorectal polyps. The role of these factors in the pathology of colorectal polyps deserves further investigation.

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Acknowledgements

This work was supported by grants from Fondo de Inversión Sanitaria del Instituto Carlos III (FIS-PI070306 and EXPTE: PI070306) and FICEMU.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Author information

Affiliations

  1. Unidad de Investigación, Hospital de Jove, Avenida Eduardo Castro s/n, C.P. 33290, Gijón, Asturias, Spain

    Noemí Eiró, Lucía González, Luis O. González, Alejandro Andicoechea, María Fernández-Díaz, Antonio Altadill & Francisco J. Vizoso

  2. Servicio de Anatomía Patológica, Hospital de Jove, Gijón, Spain

    Luis O. González

  3. Servicio de Cirugía General, Hospital de Jove, Gijón, Spain

    Alejandro Andicoechea & Francisco J. Vizoso

  4. Servicio de Medicina Interna, Hospital de Jove, Gijón, Spain

    Antonio Altadill

Authors
  1. Noemí Eiró
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  2. Lucía González
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  3. Luis O. González
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  4. Alejandro Andicoechea
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  5. María Fernández-Díaz
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  6. Antonio Altadill
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  7. Francisco J. Vizoso
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Corresponding author

Correspondence to Francisco J. Vizoso.

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Eiró, N., González, L., González, L.O. et al. Study of the Expression of Toll-Like Receptors in Different Histological Types of Colorectal Polyps and Their Relationship with Colorectal Cancer. J Clin Immunol 32, 848–854 (2012). https://doi.org/10.1007/s10875-012-9666-3

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  • DOI: https://doi.org/10.1007/s10875-012-9666-3

Keywords

  • Polyps
  • TLR
  • colorectal cancer
  • prognosis
  • stromal fibroblast