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Primary Immunodeficiencies: A 27-Year Review at a Tertiary Paediatric Hospital in Cape Town, South Africa

Journal of Clinical Immunology volume 31, pages 99–105 (2011)Cite this article

Abstract

Introduction

The epidemiology of primary immunodeficiencies (PID) is not well documented in Africa. The objective of this study was to describe the spectrum of PID at a tertiary paediatric centre in South Africa.

Methods

A retrospective study was conducted on 168 patients diagnosed with PID from 1983 to 2009.

Results

Over the study period, antibody deficiencies predominated (51%) followed by well-defined syndromes (24%). Common variable immunodeficiency was the commonest antibody deficiency. The mean age of diagnosis was 51 months overall but decreased significantly to 35 months over the last 9 years. Recurrent infections were the most common presenting complaint (74%). The overall mortality rate was 25% while combined immunodeficiencies accounted for 40% of the deaths.

Conclusions

The spectrum of PID in South Africa was similar to international trends. The declining mean age of diagnosis indicated improved recognition of PID. Future research should focus on identifying children with PID more effectively.

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Acknowledgements

Dr. R. Naidoo is an infectious diseases fellow supported by PEPFAR/USAID through the ANOVA Health Institute.

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Affiliations

  1. Paediatric Infectious Diseases Unit, Red Cross War Memorial Children’s Hospital and the School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa

    Reené Naidoo, Margaret Cooper, Sandra Pienaar & Brian S. Eley

  2. Department of Pathology, Red Cross War Memorial Children’s Hospital, National Health Laboratory Services, Cape Town, South Africa

    Lisa Ungerer

  3. Paediatric Infectious Diseases Unit, Red Cross War Memorial Children’s Hospital, Klipfontein Road, Rondebosch, Cape Town, 7700, South Africa

    Reené Naidoo

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  1. Reené Naidoo
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  2. Lisa Ungerer
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  3. Margaret Cooper
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  4. Sandra Pienaar
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  5. Brian S. Eley
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Correspondence to Reené Naidoo.

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Naidoo, R., Ungerer, L., Cooper, M. et al. Primary Immunodeficiencies: A 27-Year Review at a Tertiary Paediatric Hospital in Cape Town, South Africa. J Clin Immunol 31, 99–105 (2011). https://doi.org/10.1007/s10875-010-9465-7

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  • DOI: https://doi.org/10.1007/s10875-010-9465-7

Keywords

  • Primary immunodeficiencies
  • children
  • South Africa
  • epidemiology