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Genetic Contribution to Carotid Vascular Disease in Patients with Systemic Lupus Erythematosus

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Abstract

Objective

We investigated whether stromelysin, a candidate gene in atherogenesis, plays a role in atherogenesis of systemic lupus erythematosus (SLE), a leading cause of mortality in SLE.

Patients and Methods

A genetic study using polymorphism located in the promoter region of stromelysin was performed in 55 Italian patients with SLE. Carotid intimal-medial thickness (IMT) was evaluated by B mode ultrasonography.

Results

All patients with an “abnormal” (≥0.9 mm) IMT carried at least one 6A allele, and the degree of IMT was significantly greater in patients carrying at least one 6A allele (0.63 ± 0.22 vs 0.43 ± 0.04 mm, 5A/6A + 6A/6A vs 5A/5A, p = 0.018).

Conclusion

Our data show that polymorphism of stromelysin promoter may be relevant for SLE-related cardiovascular disease.

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Authors and Affiliations

  1. Rheumatology Unit, IRCCS Humanitas Clinical Institute, Rozzano, Milan, Italy

    Bianca Marasini & Marco Massarotti

  2. Surgery Unit, San Paolo Hospital, Milan, Italy

    Marco De Monti & Giorgio Ghilardi

  3. Molecular Biology Laboratory, San Paolo Hospital, Milan, Italy

    Maddalena Erario & Maria Luisa Biondi

Authors
  1. Bianca Marasini
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  2. Marco Massarotti
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  3. Marco De Monti
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  4. Maddalena Erario
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  5. Giorgio Ghilardi
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  6. Maria Luisa Biondi
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Corresponding author

Correspondence to Marco Massarotti.

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Marasini, B., Massarotti, M., De Monti, M. et al. Genetic Contribution to Carotid Vascular Disease in Patients with Systemic Lupus Erythematosus. J Clin Immunol 28, 131–133 (2008). https://doi.org/10.1007/s10875-007-9146-3

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  • DOI: https://doi.org/10.1007/s10875-007-9146-3

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