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“Spicing Up” of the Immune System by Curcumin

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Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. Traditionally known for its an antiinflammatory effects, curcumin has been shown in the last two decades to be a potent immunomodulatory agent that can modulate the activation of T cells, B cells, macrophages, neutrophils, natural killer cells, and dendritic cells. Curcumin can also downregulate the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12, and chemokines, most likely through inactivation of the transcription factor NF-κB. Interestingly, however, curcumin at low doses can also enhance antibody responses. This suggests that curcumin’s reported beneficial effects in arthritis, allergy, asthma, atherosclerosis, heart disease, Alzheimer’s disease, diabetes, and cancer might be due in part to its ability to modulate the immune system. Together, these findings warrant further consideration of curcumin as a therapy for immune disorders.

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ACKNOWLEDGMENTS

We would like to thank Walter Pagel for carefully proofreading the manuscript and providing valuable comments. Dr. Aggarwal is a Ransom Horne, Jr., Professor of Cancer Research. This work was supported by a grant from the Clayton Foundation for Research (to B. B. A.), National Institutes of Health PO1 grant CA91844 on lung chemoprevention (to B. B. A.), National Institutes of Health P50 Head and Neck SPORE grant P50CA97007 (to B. B. A); and a core grant (CA16672).

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  1. Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

    Ganesh Chandra Jagetia & Bharat B. Aggarwal

  2. Department of Experimental Therapeutics, Unit 143, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, 77030, USA

    Bharat B. Aggarwal

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  1. Ganesh Chandra Jagetia
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Correspondence to Bharat B. Aggarwal.

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Jagetia, G.C., Aggarwal, B.B. “Spicing Up” of the Immune System by Curcumin. J Clin Immunol 27, 19–35 (2007). https://doi.org/10.1007/s10875-006-9066-7

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