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Different Proinflammatory Cytokine Serum Pattern in Neonate Patients Undergoing Open Heart Surgery. Relevance of IL-8

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Abstract

The purpose of this work was to investigate the clinical significance of serum levels of proinflammatory cytokines in pediatric patients undergoing cardiopulmonary bypass. We divided the patients in two groups: 8 neonates, and 19 non-newborn children. IL-1β, IL-6, IL-8, and TNF serum levels were quantified before sternotomy, at admission to the PICU (30 min postoperatively), 24 h after the onset of surgery and 3 days after the operation. Surgical cardiac stress elicits significant increments of IL-6, IL-8 and TNF serum concentrations in both neonates and non-neonates, regardless of their preoperative clinical condition. However, in newborns the magnitude of the proinflammatory cytokine increments was, in particular with IL-8, remarkably greater than in older children. Moreover, neonate and non-neonate patients showed clearly disparate patterns of serum concentrations over time of both IL-8 and TNF. There was a marked relationship between IL-8 levels and postoperative morbidity, evaluated by pulmonary dysfunction, days on inotropic support and days of PICU stay in both neonates and non-neonates patients. In contrast, we found no relationship between serum levels of IL-6 and TNF and postoperative clinical data. Newborn and non-newborn patients undergoing cardiopulmonary bypass exhibit dissimilar patterns of proinflammatory cytokines. IL-8 might be implicated in the multiorganic dysfunction related to cardiopulmonary bypass in pediatric patients.

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Authors and Affiliations

  1. Departamento de Pediatría y Cirugía Pediátrica, Unidad de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    A. J. Alcaraz, L. Sancho & E. Maroto

  2. Servicio de Medicina Interna, Hospital Universitario Ramón y Cajal, Spain

    L. Manzano

  3. Laboratorio de Inmunología Clínica, Unidad Asociada I+D al Centro Superior de Investigaciones Científicas, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain

    L. Manzano, F. Esquivel, E. Reyes & M. Alvarez-Mon

  4. Servicio de Estadística, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    M. D. Vigil

  5. Servicio de Enfermedades del Sistema Inmune y Oncología, Hospital Universitario Príncipe de Asturias, Madrid, Spain

    M. Alvarez-Mon

  6. Departamento de Medicina, Universidad de Alcalá, Alcalá de Henares, 18.871, Madrid, Spain

    M. Alvarez-Mon

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  1. A. J. Alcaraz
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  2. L. Manzano
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  3. L. Sancho
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  4. M. D. Vigil
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  5. F. Esquivel
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  6. E. Maroto
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  7. E. Reyes
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  8. M. Alvarez-Mon
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Correspondence to M. Alvarez-Mon.

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Alcaraz, A.J., Manzano, L., Sancho, L. et al. Different Proinflammatory Cytokine Serum Pattern in Neonate Patients Undergoing Open Heart Surgery. Relevance of IL-8. J Clin Immunol 25, 238–245 (2005). https://doi.org/10.1007/s10875-005-4081-7

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  • DOI: https://doi.org/10.1007/s10875-005-4081-7

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