Journal of Chemical Crystallography

, Volume 44, Issue 4, pp 205–209

The Synthesis and Crystal Structure of Cbz-[(1R,2S)-ACPC]3-OH: A Tripeptide Derived from the β-Amino Acid (1R,2S)-Cispentacin

  • Stephen G. Davies
  • Elin Siddall
  • Amber L. Thompson
  • James E. Thomson
Original Paper

Abstract

Crystals of the tripeptide Cbz-[(1R,2S)-ACPC]3-OH 4, derived from the β-amino acid (1R,2S)-2-aminocyclopentanecarboxylic acid, were synthesised and studied by X-ray diffraction. Tripeptide 4 crystallizes in the orthorhombic space group P 212121 with cell parameters of a = 7.8957(1) Å, b = 12.9289(2) Å, c = 24.7850(4) Å, V = 2530.12(6) Å3 and Z = 4. Adjacent molecules are linked by a series of N–H···O=C and O–H···O=C hydrogen bonds to form a double tape-like arrangement.

Graphical Abstract

The structure of a tripeptide derived from the β-amino acid (1R,2S)-2-aminocyclopentanecarboxylic acid has been analysed by X-ray diffraction.

Keywords

β-Peptide β-Sheet Cispentacin 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Stephen G. Davies
    • 1
  • Elin Siddall
    • 1
  • Amber L. Thompson
    • 1
  • James E. Thomson
    • 1
  1. 1.Department of Chemistry, Chemistry Research LaboratoryUniversity of OxfordOxfordUK

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