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The Crystal Structure of 1-[2-(furan-2-yl)-6-methyl-1,2,3,4-tetrahydroquinolin-4-yl]Pyrrolidin-2-one

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Abstract

The title compound, C18H20N2O2, a potential pharmaceutical agent, crystallizes in the monoclinic P21/n space group with unit cell parameters a = 11.157 (7) Å, b = 8.776 (6) Å, c = 16.460 (11) Å, β = 103.08 (3)°. The tetrahydroquinoline ring system formed by the fusion of the benzene ring and the piperidine ring via two carbon atoms is coplanar, with the later adopting a sofa conformation. The pyrrolidine group in position 4 adopts an envelope conformation. Dimers related by inversion centers and linked by hydrogen bonds of the type N–H···O form cycles described by the graph set R 22 (16). Additionally, the dimers connect through weak hydrogen bonds of the type C–H···O with graph set C(10) to form chains extending along [001].

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Acknowledgments

Authors wish to thank CDCHT-ULA and FONACIT-Venezuela (grant LAB-97000821).

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Authors and Affiliations

  1. Laboratorio de Cristalografía, Departamento de Química, Facultad de Ciencias, Universidad de Los Andes, Mérida, 5101, Venezuela

    Luis A. Vizcaya, Asiloé J. Mora & Gerzon E. Delgado

  2. Laboratorio de Resonancia Magnética Nuclear, Departamento de Química, Facultad de Ciencias, Universidad de Los Andes, Mérida, 5101, Venezuela

    Ali Bahsas

  3. Escuela de Química, Universidad Industrial de Santander, Bucaramanga, Colombia

    Uriel Mora & Vladimir V. Kouznetsov

Authors
  1. Luis A. Vizcaya
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  2. Asiloé J. Mora
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  3. Gerzon E. Delgado
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  4. Ali Bahsas
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  5. Uriel Mora
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  6. Vladimir V. Kouznetsov
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Correspondence to Gerzon E. Delgado.

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Vizcaya, L.A., Mora, A.J., Delgado, G.E. et al. The Crystal Structure of 1-[2-(furan-2-yl)-6-methyl-1,2,3,4-tetrahydroquinolin-4-yl]Pyrrolidin-2-one. J Chem Crystallogr 42, 267–270 (2012). https://doi.org/10.1007/s10870-011-0237-x

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  • DOI: https://doi.org/10.1007/s10870-011-0237-x

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