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Two Novel Potential Anticonvulsant Salts of 5-Amino-2-Sulfonamide-1,3,4-Thiadiazole

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Abstract

Two crystal structures of sulfonamide salts were studied by X-Ray diffraction. The compound C2H5N4O2S2 +·H2O·Cl− (I), (Hats·H2O·Cl, Hats = protonated 5-amino-2-sulfonamide-1,3,4-thiadiazole) crystallizes in orthorhombic space group, P212121, with unit cell parameters a = 10.047(4), b = 5.186(2), c = 16.766(6) Å and the compound C2H5N4O2S2 +·CH3O3S− (II), crystallizes in monoclinic space group, Cc, with unit cell parameters a = 5.378(3), b = 19.707(6), c = 10.014(5) Å, beta = 99.97(1)°. The molecules in compound I are arranged in a helix of alternating water and Hats molecules. Helixes are interconnected by hydrogen bonds provided by Cl− ions and one ring with a graph set R 46 (12) is determined. The crystal structure of compound II presents mesylate and Hats molecules bonded by two hydrogen bond determining a ring with a graph set R 22 (8).

Index abstract

Two substituted sulfonamide salts were obtained, the hydrochloride is monohydrate and develops a helix arrangement of alternating water/sulfonamide molecules, meanwhile the mesylate is bonded to sulfonamide molecule determining a ring, with a graph set R 22 (8).

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Acknowledgments

J.R.A.D. thanks a UNSL fellowship. We thank the financial support of ANPCyT (Project PICT 25459), SECyT-UNSL (Project 7707) and CONICET (PIP Nº 01360/08). We are grateful to S.C.S.I.E. (X-ray section) of University of Valencia for provision of the X-ray crystallographic facilities. J.C.P. is member of CONICET.

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Authors and Affiliations

  1. Área de Química General e Inorgánica, “Dr. G. F. Puelles”, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 917, 5700, San Luis, Argentina

    Jorge R. A. Díaz, Gerardo E. Camí & José C. Pedregosa

  2. S.C.S.I.E. (Unidad de Rayos X)—Facultad de Física, Universidad de Valencia,, Av., Moliner 50, Burjassot, 46100, Valencia, Spain

    Malva L. González

  3. Grupo Materia Condensada, GIyA, GAIyANN, Comisión Nacional de Energía Atómica, Av. Gral Paz 1499, 1650, San Martín, Buenos Aires, Argentina

    Daniel R. Vega

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  1. Jorge R. A. Díaz
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  2. Gerardo E. Camí
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  3. Malva L. González
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  4. José C. Pedregosa
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  5. Daniel R. Vega
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Correspondence to Daniel R. Vega.

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Díaz, J.R.A., Camí, G.E., González, M.L. et al. Two Novel Potential Anticonvulsant Salts of 5-Amino-2-Sulfonamide-1,3,4-Thiadiazole. J Chem Crystallogr 41, 1114–1119 (2011). https://doi.org/10.1007/s10870-011-0054-2

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