Abstract
(S)-N-(2-Hydroxyphenyl)pyrrolidine-2-carboxamide was synthesized from Cbz-l-proline through two steps and characterized by NMR and MS. The crystal structure was determined from single-crystal X-ray diffraction data. It crystallizes in the monoclinic space group, P21, with unit cell dimensions a = 7.284(6) Å, b = 10.262(9) Å, and c = 7.975(7) Å, α = 90.00°, β = 114.451(14)°, γ = 90.00° and Z = 2. The absolute configuration of the chiral center is determined as S. In the crystal structure, intermolecular and intramolecular hydrogen bonds are responsible for the formation of a 1-dimensional network.
Index Abstract
[(S)-N-(2-Hydroxyphenyl)pyrrolidine-2-carboxamide was synthesized from Cbz-l-proline through two steps and characterized by NMR and MS. The crystal structure was determined from single-crystal X-ray diffraction data. It crystallizes in the monoclinic space group, P21, with unit cell dimensions a = 7.284(6) Å, b = 10.262(9) Å, and c = 7.975(7) Å, α = 90.00°, β = 114.451(14)°, γ = 90.00° and Z = 2. The absolute configuration of the chiral center is determined as S. In the crystal structure, intermolecular and intramolecular hydrogen bonds are responsible for the formation of a 1-dimensional network.
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Acknowledgments
This work was financially supported by the grants from Scientific Research Plan Projects of Natural Science Research Plan Projects of Shaanxi Science and Technology Department (SJ08B20) and Scientific Research Plan Projects of Shaanxi Education Department (09JK702).
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Chen, G., Tang, Y., Zhang, QZ. et al. Crystal and Molecular Structure of (S)-N-(2-Hydroxyphenyl)pyrrolidine-2-carboxamide. J Chem Crystallogr 41, 251–254 (2011). https://doi.org/10.1007/s10870-010-9935-z
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DOI: https://doi.org/10.1007/s10870-010-9935-z