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Synthesis, Crystal Structure and Cytotoxic Property of Bis(4-chlorobenzoato)bis[1-(2-aminoethyl)piperidine]disilver(I)

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Abstract

4-Chlorobenzoic acid reacts with silver oxide and 1-(2-aminoethyl)piperidine to give a dinuclear silver(I) complex, [Ag2(C7H4ClO2)2(C7H16N2)2]. The complex was characterized by elemental analysis and X-ray diffraction. The complex crystallizes in the triclinic space group P−1 with unit cell dimensions a = 6.8550(10), b = 8.7370(10), c = 13.859(2) Å, α = 73.213(3), β = 87.945(3), γ = 77.050(3)°, V = 774.09(18) Å3, Z = 1, R 1 = 0.0386, and wR 2 = 0.0791. The dimeric Ag complex is located on an inversion center. The Ag atom in the complex is three-coordinated by two N atoms from two 1-(2-aminoethyl)piperidine ligands and by one O atom of a 4-chlorobenzoate ligand, forming a triangular coordination. In the crystal structure, the molecules are linked through intermolecular N–H···O hydrogen bonds, forming chains running along the a axis. The complex shows high cytotoxic property to both normal and carcinoma cells.

Graphical Abstract

The synthesis, crystal structure and cytotoxic property of a new silver(I) complex has been presented.

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Acknowledgments

This work was supported by the Science and Technology Support Projects of Gansu Province (Grant No. 097GKCA028) and by the ‘Qing Lan’ Talent Engineering Funds by the Lanzhou Jiaotong University.

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Authors and Affiliations

  1. School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, People’s Republic of China

    Nong Wang & Bo Li

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  1. Nong Wang
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  2. Bo Li
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Correspondence to Nong Wang.

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Wang, N., Li, B. Synthesis, Crystal Structure and Cytotoxic Property of Bis(4-chlorobenzoato)bis[1-(2-aminoethyl)piperidine]disilver(I). J Chem Crystallogr 41, 219–222 (2011). https://doi.org/10.1007/s10870-010-9867-7

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  • DOI: https://doi.org/10.1007/s10870-010-9867-7

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