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Nickel(II) and Cobalt(II) Complexes with Symmetrical Four-Dentate Ligands: Crystal Structures, Characterization, and Initial DNA Binding Mechanism Research

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Abstract

Four new nickel(II) and cobalt(II) complexes of Schiff base ligands: [Ni(L)Cl2]·2H2O (I), [Ni(L)(H2O)2] (NO3)2 (II), [Ni(L)(H2O)2] (ClO4)2 (III), and [Co(L) (H2O)2] (NO3)2 (IV) (L = 1,3-[bis(pyridine-2-imino)]propane) have been synthesized. The four complexes have been fully characterized by elemental analysis, IR, absorption spectra, emission spectra, and single-crystal X-ray diffraction analysis. The binding of the four complexes to calf thymus DNA (CT DNA) has been investigated by absorption spectra and emission spectra. The results of the two methods indicate that the action mode of complex I with DNA is intercalative mainly, and the action mode of complexes II, III, IV with DNA cannot be concluded, it should be sustained by other experimental measurements.

Graphical Abstract

Four new nickel(II) and cobalt(II) complexes of Schiff base ligands: [Ni(L)Cl2]·2H2O (I), [Ni(L)(H2O)2] (NO3)2 (II), [Ni(L)(H2O)2] (ClO4)2 (III), and [Co(L) (H2O)2] (NO3)2 (IV) (L = 1,3-[bis(pyridine-2-imino)]propane) were synthesized and their crystal structures were determined. The binding of the four complexes to calf thymus DNA (CT DNA) has been investigated.

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Acknowledgments

The authors thank National Natural Science Foundation of China (No.20671076 and No. 20601018), National Science and Technology Pillar Program of China (No. 2007BAB17B02), Natural Science Foundation of Shaanxi Province (No. 2009JQ2001), Special Foundation of Shaanxi Education Section (No. 09JK792), and the Key Laboratory Research and Establish Program of Shaanxi Education Section, China (No. 03JS006) for their financial support of this work.

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Authors and Affiliations

  1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Shaanxi Key Laboratory of Physico-Inorganic Chemistry, Department of Chemistry, Northwest University, 710069, Xi’an, Shaanxi, China

    Rong-Lan Zhang, Jian-She Zhao & Qi-Zhen Shi

  2. Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, 030006, Taiyuan, China

    Rong-Lan Zhang & Pin Yang

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  1. Rong-Lan Zhang
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Correspondence to Jian-She Zhao.

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Zhang, RL., Zhao, JS., Yang, P. et al. Nickel(II) and Cobalt(II) Complexes with Symmetrical Four-Dentate Ligands: Crystal Structures, Characterization, and Initial DNA Binding Mechanism Research. J Chem Crystallogr 40, 357–368 (2010). https://doi.org/10.1007/s10870-009-9661-6

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