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Crystal Structure of the Dihydrogen Phosphate Salt of Ozagrel (ozagrel=(E)-3-[4-(1H-Imidiazol-1-ylmethyl)phenyl]-2-Propenic Acid)

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Abstract

Ozagrel, (E)-3-[4-(1H-Imidiazol-1-ylmethyl)phenyl]-2-propenic acid, crystallizes with phosphoric acid from aqueous solution to give the dihydrogen phosphate salt of ozagrel which crystallizes in the orthorhombic space group P212121 with a = 4.6901(14), b = 8.929(4), c = 34.558(13) Å, V = 1447.2(9) Å3, Z = 4, C13H15N2O6P, M r  = 326.24, D c  = 1.497 g/cm3. In the crystal structure, phosphate anions interact with ozagrel through two kinds of hydrogen bonds forming a 1D hydrogen-bonded chain. Phosphate anions are hydrogen-bonded to each other through supramolecular synthon R 33 (12) forming a 1D double-chain structure which links ozagrel molecules into a 3D structure.

Index Abstract

In crystal structure of the title compound, phosphate anions interact with ozagrel through two kinds of hydrogen bonds forming a 1D hydrogen-bonded chain. Phosphate anions are hydrogen-bonded to each other through supramolecular synthon R 33 (12) forming a 1D double-chain structure which links ozagrel molecules into a 3D structure.

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Acknowledgments

The authors acknowledge the supports from the Project of the Natural Science Foundation of Fujian Province, China (E0610024), Research Project of Education Bureau of Fujian Province, China(JA06052) and the Project from Fuzhou Municipal Bureau of Science and Technology (2007-Z-81).

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Authors and Affiliations

  1. Department of Chemistry and Chemical Engineering, Minjiang University, 350108, Fuzhou, China

    Benyong Lou, Xia Guo & Qi Lin

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  1. Benyong Lou
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  2. Xia Guo
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Correspondence to Benyong Lou.

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Lou, B., Guo, X. & Lin, Q. Crystal Structure of the Dihydrogen Phosphate Salt of Ozagrel (ozagrel=(E)-3-[4-(1H-Imidiazol-1-ylmethyl)phenyl]-2-Propenic Acid). J Chem Crystallogr 39, 469–473 (2009). https://doi.org/10.1007/s10870-008-9504-x

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  • DOI: https://doi.org/10.1007/s10870-008-9504-x

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