Synthesis and Crystal Structure of 4-Methyl-6H-pyrido[3,2,1-jk]carbazol-6-one

Abstract

The synthesis, NMR and X-ray structure of 4-methyl-6H-pyrido[3,2,1-jk]carbazol-6-one—a potential DNA intercalator are reported. The compound crystallizes in the orthorhombic Pbca space group with unit cell parameters: a = 7.775(8), b = 15.113(7), c = 19.849(7) Å, V = 2332.8(3) Å3, Mr = 233.26 and Z = 8. In the three-dimensional arrangement of the molecules no classical hydrogen bonds were found; weak π···π and C–H···O interactions are responsible for the packing of the molecules in the crystal structure.

Index Abstract

In the three-dimensional arrangement of the title compound no classical hydrogen bonds were found; weak π···π and C–H···O interactions are responsible for the packing of the molecules in the crystal structure.

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Acknowledgment

The authors thank the National Research Fund of Bulgaria for financial support; Grant TK357/TK358/VUH 03/05 VU 986.

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Correspondence to Boris Shivachev.

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Shivachev, B., Petrov, P. & Stoyanova, M. Synthesis and Crystal Structure of 4-Methyl-6H-pyrido[3,2,1-jk]carbazol-6-one. J Chem Crystallogr 39, 209–212 (2009). https://doi.org/10.1007/s10870-008-9459-y

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Keywords

  • DNA intercalator
  • Crystal structure
  • π···π Interactions
  • NMR