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Synthesis, Crystal Structure and DNA-Binding Study of a New Copper(II) Complex Containing Mixed-Ligand of Iminodiacetate Dianion and 6-Nitro-1H-benzimidazole

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Abstract

A mixed-ligand complex Cu(IDA)(NBZIM)(H2O) (IDA = iminodiacetate dianion, NBZIM = 6-nitro-1H-benzimidazole) has been synthesized and characterized by elementary analysis, IR, UV-Vis, molar conductivity and single crystal X-ray diffraction. It crystallizes in the triclinic system, space group P \( \ifmmode\expandafter\bar\else\expandafter\=\fi{1}, \) with a = 6.9423(14), b = 9.3100(19), c = 11.754(2) Å, α = 69.61(3), β = 85.87(3), γ = 83.87(3)°, Z = 2, R 1 = 0.0463 and ωR 2 = 0.0987. The single crystal X-ray analysis reveals that the Cu(II) atom is coordinated by one tridentate iminodiacetate dianion, one monodentate nitrobenzimidazole molecule and one water molecule, in a distorted square base pyramidal coordination geometry. The iminodiacetate dianion chelates the Cu(II) atom in the meridional mode. A three-dimensional network is formed by hydrogen bonds and stabilized by NBZIM π-π stacking interactions. The interaction of the complex with Fish sperm DNA has also been studied using absorption spectra.

Index Abstract

In the crystal of Cu(IDA)(NBZIM)(H2O), each molecule is linked to other six neighbouring ones by ‘eight’ hydrogen bonds in four cases by means of the ‘symmetry related’ linkage.

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Acknowledgements

We acknowledge the financial support of the National Natural Science Foundation of China (No. 30672515) and the Ph.D. Program Foundation of Ministry of Education of China (No. 20060423005).

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Authors and Affiliations

  1. Marine Drug & Food Institute, Ocean University of China, 5 Yushan Road, Qingdao, Shandong, 266003, P.R. China

    Wan-Ju Zhang, Yan-Tuan Li, Zhi-Qiang Liu & Zhi-Chao Zheng

  2. Key Laboratory of Marine Drug, Chinese Ministry of Education, Ocean University of China, Qingdao, Shandong, 266003, P.R. China

    Zhi-Yong Wu

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  1. Wan-Ju Zhang
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  2. Yan-Tuan Li
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Correspondence to Yan-Tuan Li.

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Zhang, WJ., Li, YT., Wu, ZY. et al. Synthesis, Crystal Structure and DNA-Binding Study of a New Copper(II) Complex Containing Mixed-Ligand of Iminodiacetate Dianion and 6-Nitro-1H-benzimidazole. J Chem Crystallogr 38, 655–658 (2008). https://doi.org/10.1007/s10870-008-9372-4

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  • DOI: https://doi.org/10.1007/s10870-008-9372-4

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