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The Syntheses and Crystal Structures of Metronidazole-derived Compounds

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Abstract

Metronidazole (MET-OH), widely used as an antibacterial agent, is found to have some side effects on human bodies. Due to these disadvantages, people have been looking for its modification compounds for substituents. In this article, four MET-OH derivatives were designed, prepared, and structurally characterized by single crystal X-ray diffraction. These compounds are MET-OTs (1), MET-Br (2), MET-Cl (3), and MET-I (4). X-ray structure analyses revealed that, 1 crystallized in the monoclinic system with space group P2 1 /c, with a = 16.1178, b = 7.5473, c = 13.4161 Å, V = 1520.3 Å3, β = 111.3210o and Z = 4. 2 crystallized in the monoclinic system with space group P2 1 /c, with a = 12.079, b = 11.089, c = 6.380 Å, V = 847.1 Å3, β = 97.57o and Z = 4. 3 crystallized in the monoclinic system with space group P2 1 /c, with a = 12.098, b = 11.007, c = 6.295 Å, V = 830.3 Å3, β = 97.886o and Z = 4. 4 crystallized in the triclinic system with space group P1, with a = 6.192, b = 7.740, c = 10.001 Å, V = 457.9 Å3, α = 89.073, β = 86.903, γ = 73.097o and Z = 2.

Index Abstract

In this article, metronidazole-derived compounds were prepared and structurally characterized by single crystal X-ray diffraction

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Authors and Affiliations

  1. Engineering Research Center for Clean Production of Textile Dyeing and Printing, Ministry of Education, Wuhan University of Science and Engineering, Wuhan, 430073, P. R. China

    Huan-Qiu Li, Zhu-Ping Xiao, Rui-Qin Fang & Hai-Liang Zhu

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  1. Huan-Qiu Li
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  2. Zhu-Ping Xiao
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  3. Rui-Qin Fang
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  4. Hai-Liang Zhu
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Correspondence to Hai-Liang Zhu.

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Li, HQ., Xiao, ZP., Fang, RQ. et al. The Syntheses and Crystal Structures of Metronidazole-derived Compounds. J Chem Crystallogr 38, 461–466 (2008). https://doi.org/10.1007/s10870-008-9343-9

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  • DOI: https://doi.org/10.1007/s10870-008-9343-9

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