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Synthesis and Structural Conformation Studies of a Potent Unsymmetrical 1,4-Dihydropyridine

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Abstract

2,6-Dimethyl-5-(phenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate was synthesized in two steps and was characterized spectroscopically and confirmed by X-ray diffraction studies. The molecule crystallizes in the monoclinic crystal class in the spacegroup P21/c with cell parameters a = 10.5960(6) Å, b = 10.2450(7) Å, c = 19.5790(11) Å, β = 107.448(3)° and Z = 4. The 1,4-dihydropyridine ring in the structure adopts a flattened boat conformation.

Graphical Abstract

2,6-Dimethyl-5-(phenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate was synthesized in two steps and was characterized spectroscopically and confirmed by X-ray diffraction studies. The molecule crystallizes in the monoclinic crystal class in the spacegroup P21/c with cell parameters a = 10.5960(6) Å, b = 10.2450(7) Å, c = 19.5790(11) Å, β = 107.448(3)° and Z = 4. The 1,4-dihydropyridine ring in the structure adopts a flattened boat conformation.

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Acknowledgements

The authors are thankful to Department of Chemistry, Saurashtra University, Rajkot for providing laboratory facility and DST, Government of India for financial assistance under the project SP/I2/FOO/93.

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Authors and Affiliations

  1. Department of Studies in Physics, University of Mysore, Mysore, 570 006, India

    S. Naveen, Sridhar M. Anandalwar & J. Shashidhara Prasad

  2. Department of Chemistry, Saurashtra University, Rajkot, 360 005, India

    Dinesh Manvar, Arun Mishra & Anamik Shah

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  1. S. Naveen
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  2. Sridhar M. Anandalwar
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  3. J. Shashidhara Prasad
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Correspondence to Sridhar M. Anandalwar.

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Naveen, S., Anandalwar, S.M., Prasad, J.S. et al. Synthesis and Structural Conformation Studies of a Potent Unsymmetrical 1,4-Dihydropyridine. J Chem Crystallogr 38, 315–319 (2008). https://doi.org/10.1007/s10870-008-9314-1

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  • DOI: https://doi.org/10.1007/s10870-008-9314-1

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