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A New Crystal Structure of Clarithromycin

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Abstract

A new crystal structure of clarithromycin single acetonitrile solvate designated “Form III” was first determined by single crystal X-ray diffraction. The compound crystallized in the monoclinic system, P2 1 space group with a = 10.644(2) Å, b = 18.099(4) Å, c = 11.628(2) Å, α = γ = 90°, β = 95.38(3)°, V = 2230.1(8) Å3, Z = 2, D c = 1.175 g/cm3, μ = 0.087 mm−1, F(000) = 860, R 1 = 0.034, wR 2 = 0.062, S = 0.875, (Δ/σ)max = 0.001 for 2,709 observed reflections (I > 2σ (Ι)). Form III of clarithromycin, contrary to Form I, is more thermodynamically stable than Form II used currently on the market.

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A New Crystal Structure of Clarithromycin

Jian-Hua Liang, Guo-Wei Yao

A crystal structure of clarithromycin single acetonitrile solvate was first determined by single crystal X-ray diffraction.

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Acknowledgments

The authors are grateful to the Innovation Foundation of State Economic & Trade Commission P. R. China (01BK-009) and Basic Foundation of Beijing Institute of Technology (200506B4223) for financial support.

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Authors and Affiliations

  1. School of Life Science and Technology, Beijing Institute of Technology, Beijing, 100081, China

    Jian-Hua Liang & Guo-Wei Yao

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  1. Jian-Hua Liang
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  2. Guo-Wei Yao
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Correspondence to Jian-Hua Liang.

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Liang, JH., Yao, GW. A New Crystal Structure of Clarithromycin. J Chem Crystallogr 38, 61–64 (2008). https://doi.org/10.1007/s10870-007-9287-5

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