Skip to main content
SpringerLink
Log in

The Crystal and Molecular Structure of a Polymorph and a Pseudo-Polymorph of Droperidol

  • Original Paper
  • Published:
Journal of Chemical Crystallography Aims and scope Submit manuscript

Abstract

Crystals of two crystal modifications of droperidol: a hemihydrate (1) and the z polymorph (2), have been isolated and their structure determined using X-ray diffraction methods. Droperidol hemihydrate crystallized in the triclinic space group P − 1, with unit cell parameters a = 6.2842(15), b = 10.1473(8), c = 16.1850(2) Å; α = 102.554(9); β = 91.917(14); γ = 99.316(12)°; V = 991.6(3) Å3, and Z = 2. The droperidol z polymorph crystallized in the monoclinic space group P21/c, with unit cell parameters a = 20.0406(8), b = 7.4955(4), c = 12.9733(5) Å; β = 98.089(2)°; V = 1929.39(15) Å3, and Z = 4. In 1 and 2 two molecules of droperidol are joined by two N–H···O hydrogen bonds. The structure of 1 shows a possible additional hydrogen bond linking the two droperidol molecules via the water molecule.

Graphical Abstract

The crystal and molecular structure of a polymorph and a pseudo-polymorph of droperidol

A. Actins, R. Arajs, S. Belakovs, L. Orola, and M. V. Veidis

Crystals of two crystal modifications of droperidol: a hemihydrate and the z polymorph have been isolated and their structure determined using single crystal X-ray diffraction methods.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Hilfiker R (ed) (2006) Polymorphism in the pharmaceutical Industry. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

    Google Scholar 

  2. Azibi M, Draguet-Brughmans M, Bouche R (1982) Pharm Acta Helv 57:182

    CAS  Google Scholar 

  3. Blaton NM, Peeters OM, De Ranter CJ (1980) Acta Crystallogr B36:2828

    Article  Google Scholar 

  4. Klein CL, Welch J, Southall L (1989) Acta Crystallogr C45:650

    Article  Google Scholar 

  5. Farrugia LG (1999) J Appl Crystallogr 32:837

    Article  Google Scholar 

  6. Mackay S, Gilmore CJ, Edwards C, Stewart N, Shankland K (1999) maXus, Computer program for the solution and refinement of crystal structures. Bruker Nonius, The Netherlands, MacScience, Japan and The University of Glasgow

Download references

Author information

Authors and Affiliations

  1. Faculty of Chemistry, University of Latvia, Kr. Valdemara 48, Riga, 1013, Latvia

    Andris Actins, Reinis Arajs, Liana Orola & Mikelis Valdis Veidis

  2. Latvia Institute of Organic Synthesis, Aizkraukles 21, Riga, 1006, Latvia

    Sergejs Belakovs

Authors
  1. Andris Actins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Reinis Arajs
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sergejs Belakovs
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Liana Orola
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mikelis Valdis Veidis
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mikelis Valdis Veidis.

Electronic Supplementary Material

Below is the link to the electronic supplementary material.

ESM1 (PDF 164 KB)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Actins, A., Arajs, R., Belakovs, S. et al. The Crystal and Molecular Structure of a Polymorph and a Pseudo-Polymorph of Droperidol. J Chem Crystallogr 38, 169–174 (2008). https://doi.org/10.1007/s10870-007-9283-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10870-007-9283-9

Keywords

Search

Navigation