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Crystal structure of a salt complex between (S)-2-(2′-methylbenzyl)succinic acid and (R)-1-phenylethylamine

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The optically pure 2-(2′-methylbenzyl)succinic acid were obtained by the optical resolution of the racemates with the chiral host 1-phenylethylamine. The structure of the salt complex between (S)-2-(2′-methylbenzyl)succinic acid and (R)-1-phenylethylamine was first elucidated by X-ray analysis: Monoclinic, Space group P21 with a=6.0781(12) Å, b=8.8224(18) Å, c=17.675(4) Å, β=97.64(3)°, V=939.4(3) Å3, Z=2, the absolute structure parameter is 0 (9). The crystal structure indicates that the hydrogen bonds are formed between the acetate anions and the protonated amino group. The intermolecular hydrogen bond links the salt complex into a quasi-two-dimentional netlike structure.

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Acknowledgment

We are gratefully acknowledge financial support from the National Natural Science Foundation of China (No. 203900508).

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Authors and Affiliations

  1. Department of Catalysis Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, P.R. China

    Yu-min Liu

  2. College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050016, P.R. China

    Yu-min Liu & Yong-qi Hu

  3. No. 7 Department, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, P.R. China

    He Liu

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  1. Yu-min Liu
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  2. Yong-qi Hu
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Correspondence to He Liu.

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Liu, Ym., Hu, Yq. & Liu, H. Crystal structure of a salt complex between (S)-2-(2′-methylbenzyl)succinic acid and (R)-1-phenylethylamine. J Chem Crystallogr 37, 243–246 (2007). https://doi.org/10.1007/s10870-006-9111-7

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  • DOI: https://doi.org/10.1007/s10870-006-9111-7

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