Before DNA replication can be initiated a definite number of adenosine triphosphate (ATP) containing pre-replication protein complexes (pre-RCs) must be assembled and bound to DNA like in a super-critical mass. A chemically driven dynamics of the Ginzburg-Landau (GL) type is derived, using the non-equilibrium equation for binding of pre-RCs to DNA and a probabilistic conformational distribution of these protein complexes. This dynamics, in which the DNA-protein system behaves like a nonlinear elastically braced string (NEBS), can control the cell cycle via conformational transitions such that G2 cells contain exactly twice as much DNA as G1 cells. After adjustment of previously-made derivations, the model is compared with cell growth data from the T lymphocyte MLA-144.
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Matsson, L. Model of DNA Dynamics and Replication. J Biol Phys 31, 303–321 (2005). https://doi.org/10.1007/s10867-005-4635-1
- DNA replication
- cell cycle regulation
- DNA dynamics
- DNA condensation
- DNA conformation
- DNA folding
- DNA compaction
- DNA packing
- pre-replication complex
- initiator protein assembly
- origin recognition
- non-equilibrium dynamics
- Ginzburg-Landau model
- elastically braced string
- reaction coordinate