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Journal of Biological Physics

, Volume 31, Issue 3–4, pp 303–321 | Cite as

Model of DNA Dynamics and Replication

  • Leif MatssonEmail author
Article

Abstract

Before DNA replication can be initiated a definite number of adenosine triphosphate (ATP) containing pre-replication protein complexes (pre-RCs) must be assembled and bound to DNA like in a super-critical mass. A chemically driven dynamics of the Ginzburg-Landau (GL) type is derived, using the non-equilibrium equation for binding of pre-RCs to DNA and a probabilistic conformational distribution of these protein complexes. This dynamics, in which the DNA-protein system behaves like a nonlinear elastically braced string (NEBS), can control the cell cycle via conformational transitions such that G2 cells contain exactly twice as much DNA as G1 cells. After adjustment of previously-made derivations, the model is compared with cell growth data from the T lymphocyte MLA-144.

Key words

DNA replication cell cycle regulation DNA dynamics commitment initiation termination DNA condensation DNA conformation DNA folding DNA compaction DNA packing pre-replication complex initiator protein assembly origin recognition non-equilibrium dynamics Ginzburg-Landau model elastically braced string reaction coordinate 

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Department of Physics, Condensed Matter Theory DivisionGöteborg UniversityGöteborgSweden

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