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The relation of PTSD symptoms to migraine and headache-related disability among substance dependent inpatients

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Abstract

Despite emerging evidence for the comorbidity of posttraumatic stress disorder (PTSD) and migraine, few studies have examined the relation of PTSD and migraine, particularly among clinical populations at-risk for both conditions (e.g., substance-dependent patients). This study examined the role of PTSD symptoms in migraine and headache-related disability within a sample of 153 substance-dependent inpatients (37.25 % female, Mean age 36.46). PTSD symptoms predicted both migraine and headache-related disability above and beyond gender, depression and anxiety symptoms, the experience of a Criterion A traumatic event, and current alcohol use disorder. Findings highlight the strong association between migraine and PTSD symptoms in a unique population at risk for both conditions.

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Acknowledgments

Support for this study was provided in part by R21 DA022383 from the National Institute on Drug Abuse of the National Institutes of Health awarded to the third author (MTT).

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Correspondence to Michael J. McDermott.

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Dr. Smitherman receives research support from Merck. Michael J. McDermott, Joshua C. Fulwiler, Kim L. Gratz, Kevin M. Connolly and Matthew T. Tull declare that they have no conflict of interest.

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All procedures followed were in accordance with ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.

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McDermott, M.J., Fulwiler, J.C., Smitherman, T.A. et al. The relation of PTSD symptoms to migraine and headache-related disability among substance dependent inpatients. J Behav Med 39, 300–309 (2016). https://doi.org/10.1007/s10865-015-9697-3

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