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Stress generation over the course of breast cancer survivorship

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Abstract

Depressive symptoms are frequently elevated following breast cancer diagnosis. The stress generation hypothesis states that people with depression generate stressful events and these stressors lead to subsequent depression. This study tested the stress generation hypothesis over the first 5 years of cancer survivorship. Women with stage II or III breast cancer (N = 113) were accrued. Five mediation models were constructed, one for each year. Each model tested whether stressful events in each year mediated the relationship between depression at the beginning and end of that year. Stress generation was observed in the first 2 years following cancer diagnosis but not from 2 to 5 years after diagnosis. The relationship of depression to future stress in breast cancer patients may be moderated by phase of survivorship. Screening and treatment of depressive symptoms in cancer survivors may need to consider the generation of stressful events.

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Acknowledgments

The authors would like to thank the patients for their time and participation in the study. This research was supported by the National Cancer Institute (R01 CA92704; K05 CA098133); the American Cancer Society (RSGPB-03-248-01-PBP; PBR-89), US Army Medical Research and Development Command (DAMD17-94-J-4165; DAMD17-96-1-6294; DAMD17-97-1-7062), and the National Institutes of Health (M01-RR0034). The authors would also like to thank the Stress and Immunity Cancer Project team at the Ohio State University.

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  1. Department of Psychology, The Ohio State University, 159 Psychology Building, 1835 Neil Ave, Columbus, OH, 43210, USA

    Salene M. Wu & Barbara L. Andersen

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  1. Salene M. Wu
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  2. Barbara L. Andersen
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Correspondence to Salene M. Wu.

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Wu, S.M., Andersen, B.L. Stress generation over the course of breast cancer survivorship. J Behav Med 33, 250–257 (2010). https://doi.org/10.1007/s10865-010-9255-y

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