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Radioprotective effect of diethylcarbamazine on radiation-induced acute lung injury and oxidative stress in mice

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Abstract

The present study was designed to evaluate the radioprotective effect of diethylcarbamazine (DEC) against oxidative stress and acute lung injury induced by total body radiation (TBI) in mice. For study the optimum dose for radiation protection of DEC, mice were administrated with three dose of DEC (10, 50 and 100 mg/kg), once daily for eight consecutive days. Animals were exposed whole body to 5 Gy X-radiation on the 9 day. The radioprotective potential of DEC in lung tissues was assessed using oxidative stress examinations at 24 h after TBI and histopathological assay also was analyzed one week after TBI. Results from biochemical analyses demonstrated increased malonyldialdehyde (MDA), nitric oxide (NO) and protein carbonyl (PC) levels of lung tissues in only irradiated group. Histopathologic findings also showed an increase in the number of inflammatory cells and the acute lung injury in this group. DEC pretreatment significantly mitigated the oxidative stress biomarkers as well as histological damages in irradiated mice. The favorable radioprotective effect against lungs injury was observed at a dose of 10 mg/kg of DEC in mice as compared with two other doses (50 and 100 mg/kg). The data of this study showed that DEC at a dose of 10 mg/kg with having antioxidant and anti-inflammatory properties can be used as a therapeutic candidate for protecting the lung from radiation-induced damage.

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Acknowledgments

This work was supported by the Mazandaran University of Medical Sciences, Sari, Iran.

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Authors and Affiliations

  1. Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical, Sciences, Sari, Iran

    Soghra Farzipour, Zohreh Noaparast & Seyed Jalal Hosseinimehr

  2. Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

    Soghra Farzipour

  3. Department of Anatomy, Faculty of Medicine, Molecular and Cell biology Research Center, Sari, Iran

    Fereshteh Talebpour Amiri

  4. Department of Radiotherapy, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran

    Ehsan Mihandoust

  5. Department of Toxicology and Pharmacology, Mazandaran University of Medical Sciences, Sari, Iran

    Fatemeh Shaki

  6. Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Arash Ghasemi

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  1. Soghra Farzipour
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Farzipour, S., Amiri, F.T., Mihandoust, E. et al. Radioprotective effect of diethylcarbamazine on radiation-induced acute lung injury and oxidative stress in mice. J Bioenerg Biomembr 52, 39–46 (2020). https://doi.org/10.1007/s10863-019-09820-9

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