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Role of band 3 in the erythrocyte membrane structural changes under thermal fluctuations –multi scale modeling considerations

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Abstract

An attempt was made to discuss and connect various modeling approaches on various time and space scales which have been proposed in the literature in order to shed further light on the erythrocyte membrane rearrangement caused by the cortex-lipid bilayer coupling under thermal fluctuations. Roles of the main membrane constituents: (1) the actin-spectrin cortex, (2) the lipid bilayer, and (3) the trans membrane protein band 3 and their course-consequence relations were considered in the context of the cortex non linear stiffening and corresponding anomalous nature of energy dissipation. The fluctuations induce alternating expansion and compression of the membrane parts in order to ensure surface and volume conservation. The membrane structural changes were considered within two time regimes. The results indicate that the cortex non linear stiffening and corresponding anomalous nature of energy dissipation are related to the spectrin flexibility distribution and the rate of its changes. The spectrin flexibility varies from purely flexible to semi flexible. It is influenced by: (1) the number of band 3 molecules attached to single spectrin filaments, and (2) phosphorylation of the actin-junctions. The rate of spectrin flexibility changes depends on the band 3 molecules rearrangement.

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Acknowledgments

This research was funded by grant III46001 from the Ministry of Science and Environmental Protection, Republic of Serbia. The author thanks Professor Nir Gov (Department of Chemical Physics, The Weizmann Institute of Science) for discussions that inspired this work and Professor Jelena Filipovic (Faculty of Philology, University of Belgrade) for language corrections.

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  1. Faculty of Technology and Metallurgy, Belgrade University, Karnegijeva 4, Belgrade, Serbia

    Ivana Pajic-Lijakovic

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  1. Ivana Pajic-Lijakovic
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Pajic-Lijakovic, I. Role of band 3 in the erythrocyte membrane structural changes under thermal fluctuations –multi scale modeling considerations. J Bioenerg Biomembr 47, 507–518 (2015). https://doi.org/10.1007/s10863-015-9633-9

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  • DOI: https://doi.org/10.1007/s10863-015-9633-9

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