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Mitochondrial dysfunction in mouse models of Parkinson’s disease revealed by transcriptomics and proteomics

Journal of Bioenergetics and Biomembranes volume 41, pages 487–491 (2009)Cite this article

Abstract

It has been long thought that neuronal loss in Parkinson’s disease (PD) is related to reactive oxygen species from mitochondrial dysfunction. However, there have been few investigations surveying both transcriptome and proteome in PD. This review focuses on recent work using microarrays and mass spectrometry to examine neurotoxicological models of PD in the mouse. Molecular pathways involved in oxidative phosphorylation, oxidative stress, apoptosis/cell death, signal transduction and neurotransmission were highlighted. Analysis of tyrosine nitration suggested that this important post-translational modification, due to conjugation of reactive oxygen species with nitric oxide, may play an important role in signal transduction as well as the molecular pathology of PD. Thus, the combined investigations highlight known pathways in PD but also point to new directions for research, implicating particularly the role of relatively understudied classes of post-translational modifications in normal cell signaling and neurological disorders.

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Affiliations

  1. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, CHS 23-120, Box 951735, Los Angeles, CA, 90095-1735, USA

    Desmond J. Smith

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  1. Desmond J. Smith
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Correspondence to Desmond J. Smith.

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Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Smith, D.J. Mitochondrial dysfunction in mouse models of Parkinson’s disease revealed by transcriptomics and proteomics. J Bioenerg Biomembr 41, 487–491 (2009). https://doi.org/10.1007/s10863-009-9254-2

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  • DOI: https://doi.org/10.1007/s10863-009-9254-2

Keywords

  • Parkinson’s disease
  • Mitochondrion
  • Oxidative stress
  • Methamphetamine
  • MPTP