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Mitochondrial and cell-surface F0F1ATPsynthase in innate and acquired cardioprotection

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Abstract

Mitochondria are central to heart function and dysfunction, and the pathways activated by different cardioprotective interventions mostly converge on mitochondria. In a context of perspectives in innate and acquired cardioprotection, we review some recent advances in F0F1ATPsynthase structure/function and regulation in cardiac cells. We focus on three topics regarding the mitochondrial F0F1ATPsynthase and the plasma membrane enzyme, i.e.: i) the crucial role of cardiac mitochondrial F0F1ATPsynthase regulation by the inhibitory protein IF1 in heart preconditioning strategies; ii) the structure and function of mitochondrial F0F1ATPsynthase oligomers in mammalian myocardium as possible endogenous factors of mitochondria resistance to ischemic insult; iii) the external location and characterization of plasma membrane F0F1 ATP synthase in search for possible actors of its regulation, such as IF1 and calmodulin, at cell surface.

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  1. Giovanna Lippe

    Present address: Department of Food Science, University of Udine, via Sondrio 2/A, Udine, I-33100, Italy

Authors and Affiliations

  1. Department of Biomedical Sciences and Technologies and M.A.T.I. Centre of Excellence, University of Udine, P.le Kolbe 4, 33100, Udine, Italy

    Giovanna Lippe, Elena Bisetto, Marina Comelli, Stefania Contessi, Francesca Di Pancrazio & Irene Mavelli

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  1. Giovanna Lippe
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  2. Elena Bisetto
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Correspondence to Irene Mavelli.

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Lippe, G., Bisetto, E., Comelli, M. et al. Mitochondrial and cell-surface F0F1ATPsynthase in innate and acquired cardioprotection. J Bioenerg Biomembr 41, 151–157 (2009). https://doi.org/10.1007/s10863-009-9208-8

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