Abstract
There is excellent agreement between the electrophysiological properties and the structure of the mitochondrial outer membrane protein, VDAC, ex vivo. However, the inference that the well-defined canonical “open” state of the VDAC pore is the normal physiological state of the channel in vivo is being challenged by several lines of evidence. Knowing the atomic structure of the detergent solubilized protein, a long sought after goal, will not be sufficient to understand the functioning of this channel protein. In addition, detailed information about VDAC’s topology in the outer membrane of intact mitochondria, and the structural changes that it undergoes in response to different stimuli in the cell will be needed to define its physiological functions and regulation.
Similar content being viewed by others
References
Ahmadzadeh M, Horng A, Colombini M (1996) Cell Biochem Funct 14:201–208
Baines CP, Kaiser RA, Sheiko T, Craigen WJ, Molkentin JD (2007) Nat Cell Biol 9:550–555
Blachly-Dyson E, Zambronicz EB, Yu WH, Adams V, McCabe ER, Adelman J, Colombini M, Forte M (1993) J Biol Chem 268:1835–1841
Campbell AM, Chan SH (2007) Arch Biochem Biophys 466:203–210
Carneiro CM, Krasilnikov OV, Yuldasheva LN, Campos de Carvalho AC, Nogueira RA (1997) FEBS Lett 416:187–189
Carneiro CM, Merzlyak PG, Yuldasheva LN, Silva LG, Thinnes FP, Krasilnikov OV (2003) Biochim Biophys Acta 1612:144–153
Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ (2003) Science 301:513–517
De Pinto V (2008) Structure of the voltage dependent anion channel: State of the art. J Bioenerg Biomembr, this volume, doi:10.1007/s10863-008-9140-3
De Pinto V, al Jamal JA, Palmieri F (1993) J Biol Chem 268:12977–12982
De Pinto V, Ludwig O, Krause J, Benz R, Palmieri F (1987) Biochim Biophys Acta 894:109–119
Dejean LM, Martinez-Caballero S, Guo L, Hughes C, Teijido O, Ducret T, Ichas F, Korsmeyer SJ, Antonsson B, Jonas EA, Kinnally KW (2005) Mol Biol Cell 16:2424–2432
Dolder M, Zeth K, Tittmann P, Gross H, Welte W, Wallimann T (1999) J Struct Biol 127:64–71
Forte M, Blachly-Dyson E, Colombini M (1996) Soc Gen Physiol Ser 51:145–154
Galluzzi L, Kroemer G (2007) Nat Cell Biol 9:487–489
Goncalves RP, Buzhynskyy N, Prima V, Sturgis JN, Scheuring S (2007) J Mol Biol 369:413–418
Grigoriev SM, Muro C, Dejean LM, Campo ML, Martinez-Caballero S, Kinnally KW (2004) Int Rev Cytol 238:227–274
Guo XW, Mannella CA (1993) Biophys J 64:545–549
Guo XW, Smith PR, Cognon B, D’Arcangelis D, Dolginova E, Mannella CA (1995) J Struct Biol 114:41–59
Hille B (2001) Ionic channels of excitable membranes, 2nd edn. Sinauer Assoc., Sunderland, MA
Holden MJ, Colombini M (1988) FEBS Lett 241:105–109
Holden MJ, Colombini M (1993) Biochim Biophys Acta 1144:396–402
Jonas EA, Hickman JA, Chachar M, Polster BM, Brandt TA, Fannjiang Y, Ivanovska I, Basanez G, Kinnally KW, Zimmerberg J, Hardwick JM, Kaczmarek LK (2004) Proc Natl Acad Sci U S A 101:13590–13595
Kinnally KW, Tedeschi H, Mannella CA (1987) FEBS Lett 226:83–87
Kinnally KW, Tedeschi H, Mannella CA, Frisch HL (1989) Biophys J 55:1205–1213
Koppel DA, Kinnally KW, Masters P, Forte M, Blachly-Dyson E, Mannella CA (1998) J Biol Chem 273:13794–13800
Krauskopf A, Eriksson O, Craigen WJ, Forte MA, Bernardi P (2006) Biochim Biophys Acta 1757:590–595
Liu MY, Colombini M (1992) Biochim Biophys Acta 1098:255–260
Liu MY, Torgrimson A, Colombini M (1994) Biochim Biophys Acta 1185:203–212
Mannella CA (1982) J Cell Biol 94:680–687
Mannella CA (1984) Science 224:165–166
Mannella CA (1989) Biochim Biophys Acta 981:15–20
Mannella CA (1997) J Bioenerg Biomembr 29:525–531
Mannella CA (1998) J Struct Biol 121:207–218
Mannella CA, Colombini M (1984) Biochim Biophys Acta 774:206–214
Mannella CA, Tedeschi H (1987) J Bioenerg Biomembr 19:305–308
Moran O, Sciancalepore M, Sandri G, Panfili E, Bassi R, Ballarin C, Sorgato MC (1992) Eur Biophys J 20:311–319
Muro C, Grigoriev SM, Pietkiewicz D, Kinnally KW, Campo ML (2003) Biophys J 84:2981–2989
Parsons DF, Bonner WD, Verboon JG (1965) Can J Bot 43:647–655
Pavlov E, Grigoriev SM, Dejean LM, Zweihorn CL, Mannella CA, Kinnally KW (2005) Biochim Biophys Acta 1710:96–102
Pavlov EV, Priault M, Pietkiewicz D, Cheng EH, Antonsson B, Manon S, Korsmeyer SJ, Mannella CA, Kinnally KW (2001) J Cell Biol 155:725–731
Peng S, Blachly-Dyson E, Forte M, Colombini M (1992) Biophys J 62:123–131 discussion 131-5
Popp B, Court DA, Benz R, Neupert W, Lill R (1996) J Biol Chem 271:13593–13599
Rostovtseva T, Colombini M (1996) J Biol Chem 271:28006–28008
Rostovtseva T, Hassanzadeh E, Sackett D, Bezrukov S (2008) 2008 Biophysical Society Meeting Abstracts, Biophysical J., supplement, Abstract Available at http://www.biophysics.org/abstracts/
Sampson MJ, Lovell RS, Davison DB, Craigen WJ (1996) Genomics 36:192–196
Schein SJ, Colombini M, Finkelstein A (1976) J Membr Biol 30:99–120
Shao L, Kinnally KW, Mannella CA (1996) Biophys J 71:778–786
Shimizu S, Ide T, Yanagida T, Tsujimoto Y (2000a) J Biol Chem 275:12321–12325
Shimizu S, Matsuoka Y, Shinohara Y, Yoneda Y, Tsujimoto Y (2001) J Cell Biol 152:237–250
Shimizu S, Shinohara Y, Tsujimoto Y (2000b) Oncogene 19:4309–4318
Sorgato MC, Moran O (1993) Crit Rev Biochem Mol Biol 28:127–171
Stanley S, Dias JA, D’Arcangelis D, Mannella CA (1995) J Biol Chem 270:16694–16700
Tedeschi H, Kinnally KW (1987) J Bioenerg Biomembr 19:321–327
Thomas L, Blachly-Dyson E, Colombini M, Forte M (1993) Proc Natl Acad Sci U S A 90:5446–5449
Thomas L, Kocsis E, Colombini M, Erbe E, Trus BL, Steven AC (1991) J Struct Biol 106:161–171
Tsujimoto Y, Shimizu S (2000) Cell Death Differ 7:1174–1181
Vander Heiden MG, Li XX, Gottleib E, Hill RB, Thompson CB, Colombini M (2001) J Biol Chem 276:19414–19419
Verschoor A, Tivol WF, Mannella CA (2001) J Struct Biol 133:254–265
Xu X, Forbes JG, Colombini M (2001) J Membr Biol 180:73–81
Zizi M, Forte M, Blachly-Dyson E, Colombini M (1994) J Biol Chem 269:1614–1616
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mannella, C.A., Kinnally, K.W. Reflections on VDAC as a voltage-gated channel and a mitochondrial regulator. J Bioenerg Biomembr 40, 149–155 (2008). https://doi.org/10.1007/s10863-008-9143-0
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10863-008-9143-0