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The Intracellular Antigen Transport Machinery TAP in Adaptive Immunity and Virus Escape Mechanisms

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The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.

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Abbreviations

ABC:

ATP-binding cassette

MHC:

major histocompatibility complex

NBD:

nucleotide-binding domain

TAP:

transporter associated with antigen processing

TMD:

transmembrane domain

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  1. Institute of Biochemistry, Biocenter, Johann Wolfgang Goethe-University Frankfurt, Marie-Curie-Str. 9, D-60439, Frankfurt a.M., Germany

    Christian Schölz & Robert Tampé

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  1. Christian Schölz
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Schölz, C., Tampé, R. The Intracellular Antigen Transport Machinery TAP in Adaptive Immunity and Virus Escape Mechanisms. J Bioenerg Biomembr 37, 509–515 (2005). https://doi.org/10.1007/s10863-005-9500-1

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