Abstract
Behavioral activation and experiential avoidance are considered closely related transdiagnostic constructs. Decreases in behavioral activation and increases in avoidance are both thought to play a role in the maintenance of emotional disorder symptoms. Using a series of random intercept cross-lagged panel models, this study examined the temporal relations between change in behavioral activation, experiential avoidance, and anxiety symptoms during outpatient administration of the Unified Protocol. Between-person results demonstrated that greater avoidance was associated with lower activation, and more severe anxiety symptoms were associated with both greater avoidance and lower activation. Within-person results suggested that improvements in avoidance tended to predict increased activation and decreased anxiety symptoms. Changes in activation did not substantially predict changes in avoidance or anxiety. Overall, these results provide preliminary information on the timing of important therapeutic processes and may shed light on how clinicians should prioritize targets.
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Notes
Similarly, across all 12 weeks, participants reported large, significant reductions in behavioral avoidance, B = -.71, SE = .12, p < .01, 95% CI [-.96, -.47], d = .79; medium-sized, significant reductions in anxiety, B = -.16, SE = .04, p < .01, 95% CI [-.24, -.08], d = .54; and small-sized, significant increases in behavioral activation, B = .09, SE = .05, p = .03, 95% CI [.01, .19], d = .26. These 12-week changes in behavioral avoidance, B = .32, SE = .30, p = .29, 95% CI [-.29, .93]; anxiety, B = .08, SE = .08, p = .37, 95% CI [-.08, .24]; and behavioral activation, B = -.20, SE = .12, p = .11, 95% CI [-.44, .04], did not significantly differ by duration condition.
References
Akbari, M., Seydavi, M., Hosseini, Z. S., Krafft, J., & Levin, M. E. (2022). Experiential avoidance in depression, anxiety, obsessive-compulsive related, and posttraumatic stress disorders: A comprehensive systematic review and meta-analysis. Journal of Contextual Behavioral Science, 24, 65–78. https://doi-org.ezproxy.uky.edu/10.1016/j.jcbs.2022.03.007
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). https://doi.org/10.1176/appi.books.9780890425596
Arnaudova, I., Kindt, M., Fanselow, M., & Beckers, T. (2017). Pathways towards the proliferation of avoidance in anxiety and implications for treatment. Behaviour Research and Therapy, 96, 3–13. https://doi.org/10.1016/j.brat.2017.04.004
Bandelow, B., & Michaelis, S. (2015). Epidemiology of anxiety disorders in the 21st century. Dialogues in Clinical Neuroscience, 17(3), 327–335. https://doi.org/10.31887/DCNS.2015.17.3/bbandelow
Barlow, D. H., Farchione, T. J., Bullis, J. R., Gallagher, M. W., Murray-Latin, H., Sauer-Zavala, S., Bentley, K. H., Thompson-Hollands, J., Conklin, L. R., Boswell, J. F., Ametaj, A., Carl, J. R., Boettcher, H. T., & Cassiello-Robbins, C. (2017). The unified protocol for transdiagnostic treatment of emotional disorders compared with diagnosis-specific protocols for anxiety disorders: A randomized clinical trial. JAMA Psychiatry, 74(9), 875–884. https://doi-org.ezproxy.uky.edu/10.1001/jamapsychiatry.2017.2164
Barlow, D. H., Farchione, T. J., Sauer-Zavala, S., Latin, H. M., Ellard, K. K., Bullis, J. R., et al. (2018). Unified protocol for transdiagnostic treatment of emotional disorders: Therapist guide (2nd ed.). Oxford University Press.
Beard, J. I., & Delgadillo, J. (2019). Early response to psychological therapy as a predictor of depression and anxiety treatment outcomes: A systematic review and meta-analysis. Depression and Anxiety, 36, 866–878. https://doi-org.ezproxy.uky.edu/10.1002/da.22931
Bentley, K. H., Sauer-Zavala, S., Cassiello-Robbins, C. F., Conklin, L. R., Vento, S., & Homer, D. (2017). Treating suicidal thoughts and behaviors within an emotional disorders framework: Acceptability and feasibility of the unified protocol in an inpatient setting. Behavior Modification, 41(4), 529–557. https://doi-org.ezproxy.uky.edu/10.1177/0145445516689661
Blalock, J. A., & Joiner, T. E., Jr. (2000). Interaction of cognitive avoidance coping and stress in predicting depression/anxiety. Cognitive Therapy and Research, 24(1), 47–65. https://doi-org.ezproxy.uky.edu/10.1023/A:1005450908245
Bullis, J. R., Boettcher, H., Sauer, Z. S., Farchione, T. J., & Barlow, D. H. (2019). What is an emotional disorder? A transdiagnostic mechanistic definition with implications for assessment, treatment, and prevention. Clinical Psychology: Science and Practice, 26(2). https://doi-org.ezproxy.uky.edu/10.1037/h0101755.supp(Supplemental)
Campbell-Sills, L., Barlow, D. H., Brown, T. A., & Hofmann, S. G. (2006). Effects of suppression and acceptance on emotional responses of individuals with anxiety and mood disorders. Behaviour Research and Therapy, 44(9), 1251–1263. https://doi.org/10.1016/j.brat.2005.10.001
Cassiello-Robbins, C., Southward, M. W., Wilner Tirpak, J., & Sauer-Zavala, S. (2020). A systematic review of Unified Protocol applications: Facilitating widespread dissemination via adaptability. Clinical Psychology Review, 78, 101852. https://doi.org/10.1016/j.cpr.2020.101852
Dimidjian, S., Barrera, M., Jr., Martell, C., Muñoz, R. F., & Lewinsohn, P. M. (2011). The origins and current status of behavioral activation treatments for depression. Annual Review of Clinical Psychology, 7, 1–38. https://doi-org.ezproxy.uky.edu/10.1146/annurev-clinpsy-032210-104535
Drost, J., van der Does, W., van Hemert, A. M., Penninx, B. W. J. H., & Spinhoven, P. (2014). Repetitive negative thinking as a transdiagnostic factor in depression and anxiety: A conceptual replication. Behaviour Research and Therapy, 63, 177–183. https://doi.org/10.1016/j.brat.2014.06.004
Eustis, E. H., Cardona, N., Nauphal, M., Sauer-Zavala, S., Rosellini, A. J., Farchione, T. J., & Barlow, D. H. (2020). Experiential avoidance as a mechanism of change across cognitive-behavioral therapy in a sample of participants with heterogeneous anxiety disorders. Cognitive Therapy and Research, 44(2), 275–286. https://doi-org.ezproxy.uky.edu/10.1007/s10608-019-10063-6
Falkenström, F., Solomonov, N., & Rubel, J. A. (2022). How to model and interpret cross-lagged effects in psychotherapy mechanisms of change research: A comparison of multilevel and structural equation models. Journal of Consulting and Clinical Psychology, 90, 446–458. https://doi.org/10.1037/ccp0000727
Fernández-Rodríguez, C., Coto-Lesmes, R., Martínez-Loredo, V., González-Fernández, S., & Cuesta, M. (2023). Is activation the active ingredient of transdiagnostic therapies? A randomized clinical trial of behavioral activation, acceptance and commitment therapy, and transdiagnostic cognitive-behavioral therapy for emotional disorders. Behavior Modification, 47(1), 3–45. https://doi-org.ezproxy.uky.edu/10.1177/01454455221083309
Fernández-Rodríguez, C., Paz-Caballero, D., González-Fernández, S., & Pérez-Álvarez, M. (2018). Activation vs. experiential avoidance as a transdiagnostic condition of emotional distress: An empirical study. Frontiers in Psychology, 9, Article 1618. https://doi.org/10.3389/fpsyg.2018.01618
Fuhr, K., Hautzinger, M., Krisch, K., Berking, M., & Ebert, D. D. (2016). Validation of the Behavioral Activation for Depression Scale (BADS)—Psychometric properties of the long and short form. Comprehensive Psychiatry, 66, 209–218. https://doi-org.ezproxy.uky.edu/10.1016/j.comppsych.2016.02.004
Gámez, W., Chmielewski, M., Kotov, R., Ruggero, C., & Watson, D. (2011). Development of a measure of experiential avoidance: The Multidimensional Experiential Avoidance Questionnaire. Psychological Assessment, 23(3), 692–713. https://doi-org.ezproxy.uky.edu/10.1037/a0023242.supp(Supplemental)
Gill, C. C., Kane, R. T., & Mazzucchelli, T. G. (2019). Activation, avoidance, and response-contingent positive reinforcement predict subjective wellbeing. Journal of Happiness Studies: An Interdisciplinary Forum on Subjective Well-Being, 20(2), 331–349. https://doi-org.ezproxy.uky.edu/10.1007/s10902-017-9949-8
González-Fernández, S., Fernández-Rodríguez, C., Paz-Caballero, M. D., & Pérez-Álvarez, M. (2018). Treating anxiety and depression of cancer survivors: Behavioral activation versus acceptance and commitment therapy. Psicothema, 30(1), 14–20. https://doi.org/10.7334/psicothema2017.396
Groen, R. N., Ryan, O., Wigman, J. T. W., Riese, H., Penninx, B. W. J. H., Giltay, E. J., Wichers, M., & Hartman, C. A. (2020). Comorbidity between depression and anxiety: Assessing the role of bridge mental states in dynamic psychological networks. BMC Medicine, 18(1), 308–317. https://doi.org/10.1186/s12916-020-01738-z
Gross, J. J. (2015). Emotion regulation: Current status and Future Prospects. Psychological Inquiry, 26(1), 1–26. https://doi.org/10.1080/1047840x.2014.940781
Hayes, S. C., Luoma, J. B., Bond, F. W., Masuda, A., & Lillis, J. (2006). Acceptance and Commitment Therapy: Model, processes and outcomes. Behaviour Research and Therapy, 44(1), 1–25. https://doi.org/10.1016/j.brat.2005.06.006
Hayes, S. C., Wilson, K. G., Giford, E. V., Follette, V. M., & Strosahl, K. (1996). Experimental avoidance and behavioral disorders: A functional dimensional approach to diagnosis and treatment. Journal of Consulting and Clinical Psychology, 64(6), 1152–1168.
Hamaker, E., Kuiper, R. M., & Grasman, R. P. (2015). A critique of the cross-lagged panel model. Psychological Methods, 20(1), 102–116. https://doi-org.ezproxy.uky.edu/10.1037/a0038889
Hopko, D. R., Lejuez, C. W., Ruggiero, K. J., & Eifert, G. H. (2003). Contemporary behavioral activation treatments for depression: Procedures, principles, and progress. Clinical Psychology Review, 23(5), 699–717. https://doi.org/10.1016/s0272-7358(03)00070-9
Jacob, K. L., Christopher, M. S., & Neuhaus, E. C. (2011). Development and validation of the Cognitive-Behavioral Therapy Skills Questionnaire. Behavior Modification, 35(6), 595–618. https://doi-org.ezproxy.uky.edu/10.1177/0145445511419254
Jacobson, N. S., Dobson, K. S., Truax, P. A., Addis, M. E., Koerner, K., Gollan, J. K., Gortner, E., & Prince, S. E. (2000). A component analysis of cognitive–behavioral treatment for depression. Prevention & Treatment, 3(1). https://doi-org.ezproxy.uky.edu/10.1037/1522-3736.3.1.323a
Lamers, F., van Oppen, P., Comijs, H. C., Smit, J. H., Spinhoven, P., van Balkom, A. J., Nolen, W. A., Zitman, F. G., Beekman, A. T., & Penninx, B. W. (2011). Comorbidity patterns of anxiety and depressive disorders in a large cohort study: The Netherlands Study of Depression and Anxiety (NESDA). The Journal of Clinical Psychiatry, 72(3), 341–348. https://doi.org/10.4088/JCP.10m06176blu
Lejuez, C. W., Hopko, D. R., & Hopko, S. D. (2001). A brief behavioral activation treatment for depression: Treatment manual. Behavior Modification, 25(2), 255–286. https://doi.org/10.1177/0145445501252005
Manos, R. C., Kanter, J. W., & Busch, A. M. (2010). A critical review of assessment strategies to measure the behavioral activation model of depression. Clinical Psychology Review, 30(5), 547–561. https://doi-org.ezproxy.uky.edu/10.1016/j.cpr.2010.03.008
Martell, C. R., Dimidjian, S., & Herman-Dunn, R. (2010). Behavioral activation for depression: A clinician’s guide. Guilford Press.
Masselink, M., Van Roekel, E., Hankin, B. L., Keijsers, L., Lodder, G. M. A., Vanhalst, J., Verhagen, M., Young, J. F., & Oldehinkel, A. J. (2018). The longitudinal association between self-esteem and depressive symptoms in adolescents: Separating between-person effects from within-person effects. European Journal of Personality, 32(6), 653–671. https://doi.org/10.1002/per.2179
McDonnell, D., Vasiliou, V. S., Lonergan, E., & Moore, P. (2022). Psychologists’ experiences who managed waitlists in mental-health services during the COVID-19 lockdown: A mixed-method study. European Journal of Psychology Open, 81(2), 47–56. https://doi-org.ezproxy.uky.edu/10.1024/2673-8627/a000024(Supplemental)
McHugh, R. K., Murray, H. W., & Barlow, D. H. (2009). Balancing fidelity and adaptation in the dissemination of empirically-supported treatments: The promise of transdiagnostic interventions. Behaviour Research and Therapy, 47(11), 946–953. https://doi-org.ezproxy.uky.edu/10.1016/j.brat.2009.07.005
Meidlinger, P. C., & Hope, D. A. (2017). The new transdiagnostic cognitive behavioral treatments: Commentary for clinicians and clinical researchers. Journal of Anxiety Disorders, 46, 101–109. https://doi-org.ezproxy.uky.edu/10.1016/j.janxdis.2016.11.002
Merikangas, K. R., He, J. P., Burstein, M., Swanson, S. A., Avenevoli, S., Cui, L., Benjet, C., Georgiades, K., & Swendsen, J. (2010). Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication-Adolescent Supplement (NCS-A). Journal of the American Academy of Child and Adolescent Psychiatry, 49(10), 980–989. https://doi.org/10.1016/j.jaac.2010.05.017
Meyer, E. C., Walser, R., Hermann, B., Bash, H., DeBeer, B. B., Morissette, S. B., Kimbrel, N. A., Kwok, O., Batten, S. V., & Schnurr, P. P. (2018). Acceptance and commitment therapy for co‐occurring posttraumatic stress disorder and alcohol use disorders in veterans: Pilot treatment outcomes. Journal of Traumatic Stress, 31(5), 781–789. https://doi-org.ezproxy.uky.edu/10.1002/jts.22322
Norman, S. B., Cissell, S. H., Means-Christensen, A. J., & Stein, M. B. (2006). Development and validation of an Overall Anxiety Severity and Impairment Scale (OASIS). Depression and Anxiety, 23(4), 245–249. https://doi.org/10.1002/da.20182
O’Mahen, H. A., Wilkinson, E., Bagnall, K., Richards, D. A., & Swales, A. (2017). Shape of change in internet based behavioral activation treatment for depression. Behaviour Research and Therapy, 95, 107–116. https://doi.org/10.1016/j.brat.2017.05.011
Pinheiro, J., Bates, D., & R Core Team. (2023). nlme: Linear and Nonlinear Mixed Effects Models. R package version 3.1-163. https://CRAN.R-project.org/package=nlme
R Core Team. (2022). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/
Roemer, L., & Borkovec, T. D. (1994). Effects of suppressing thoughts about emotional material. Journal of Abnormal Psychology, 103(3), 467–474. https://doi.org/10.1037/0021-843X.103.3.467
Rubel, J., Lutz, W., & Schulte, D. (2015). Patterns of change in different phases of out-patient psychotherapy: A stage-sequential pattern analysis of change in session reports. Clinical Psychology & Psychotherapy, 22, 1–14. https://doi-org.ezproxy.uky.edu/10.1002/cpp.1868
Santos, M. M., Rae, J. R., Nagy, G. A., Manbeck, K. E., Hurtado, G. D., West, P., Santiago-Rivera, A., & Kanter, J. W. (2017). A client-level session-by-session evaluation of behavioral activation’s mechanism of action. Journal of Behavior Therapy and Experimental Psychiatry, 54, 93–100. https://doi.org/10.1016/j.jbtep.2016.07.003
Santos, M. M., Ullman, J., Leonard, R. C., Puspitasari, A. J., Cook, J., & Riemann, B. C. (2019). Behavioral activation as a mechanism of change in residential treatment for mood problems: A growth curve model analysis. Behavior Therapy, 50(6), 1087–1097. https://doi-org.ezproxy.uky.edu/10.1016/j.beth.2019.05.004
Sauer-Zavala, S., Southward, M. W., Stumpp, N. E., Semcho, S. A., Hood, C. O., Garlock, A., & Urs, A. (2022). A SMART approach to personalized care: How to select and sequence skills in transdiagnostic CBT. Cognitive Behaviour Therapy. Advance online publication. https://doi.org/10.1080/16506073.2022.2053571
Sakiris, N., & Berle, D. (2019). A systematic review and meta-analysis of the Unified Protocol as a transdiagnostic emotion regulation based intervention. Clinical Psychology Review, 72, 101751. https://doi.org/10.1016/j.cpr.2019.101751
Southward, M. W., Sauer-Zavala, S., & Cheavens, J. S. (2021). Specifying the mechanisms and targets of emotion regulation: A translational framework from affective science to psychological treatment. Clinical Psychology: Science and Practice, 28(2), 168–182. https://doi-org.ezproxy.uky.edu/10.1037/cps0000003
Tolin, D. F., Gilliam, C., Wootton, B. M., Bowe, W., Bragdon, L. B., Davis, E., Hannan, S. E., Steinman, S. A., Worden, B., & Hallion, L. S. (2018). Psychometric properties of a structured diagnostic interview for DSM-5 anxiety, mood, and obsessive-compulsive and related disorders. Assessment, 25(1), 3–13. https://doi.org/10.1177/1073191116638410
Wagener, A., Baeyens, C., & Blairy, S. (2016). Depressive symptomatology and the influence of the behavioral avoidance and activation: A gender-specific investigation. Journal of Affective Disorders, 193, 123–129. https://doi-org.ezproxy.uky.edu/10.1016/j.jad.2015.12.040
Wilamowska, Z. A., Thompson-Hollands, J., Fairholme, C. P., Ellard, K. K., Farchione, T. J., & Barlow, D. H. (2010). Conceptual background, development, and preliminary data from the unified protocol for transdiagnostic treatment of emotional disorders. Depression and Anxiety, 27(10), 882–890. https://doi.org/10.1002/da.20735
Zhang, C.-Q., Leeming, E., Smith, P., Chung, P.-K., Hagger, M. S., & Hayes, S. C. (2018). Acceptance and commitment therapy for health behavior change: A contextually-driven approach. Frontiers in Psychology, 8. https://doi-org.ezproxy.uky.edu/10.3389/fpsyg.2017.02350
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M.W.S.’s effort on this project was partially supported by the National Institute of Mental Health under award number K23MH126211. The content is solely the responsibility of the author and does not necessarily represent the official views of the National Institute of Health.
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Terrill, D.R., Southward, M.W., Crowley, L. et al. Temporal Relations Among Changes in Activation, Avoidance, and Anxiety in the Unified Protocol. J Psychopathol Behav Assess 46, 147–157 (2024). https://doi.org/10.1007/s10862-023-10099-9
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DOI: https://doi.org/10.1007/s10862-023-10099-9